Objective Several observational studies have shown that high-volume and high-intensity
exercise training increases the prevalence and severity of coronary atherosclerosis, but the …

Background Physical activity (PA) is considered to play an important role in the reduced gout
risk. However, the epidemiology results are inconsistent and causality remains unclear …

Background Intervertebral disc degeneration (IDD) is a common musculoskeletal disorder
that contributes significantly to disability and healthcare costs. Serum urate concentration …

Alcoholic beverages are classified as carcinogenic to humans by the International Agency
for Research on Cancer. Globally, nearly 5.5% of all cancers are attributable to alcohol use …

Introduction Lung cancer (LC) remains a leading cause of cancer mortality worldwide,
underscoring the urgent need for novel therapeutic targets. The integration of Mendelian …

Objectives Intervertebral disc degeneration (IDD) is a prevalent musculoskeletal disorder
with substantial implications for disability and healthcare expenditures. The role of serum …

Background People with cancer experience high rates of venous thromboembolism (VTE).
Risk of subsequent cancer is also increased in people experiencing their first VTE. The …

Purpose Observational studies suggest that dietary and serum calcium are risk factors for
prostate cancer. However, such studies suffer from residual confounding (due to …

Background: Previous observational studies have suggested a possible association
between periodontal disease and gastric cancer (GC); however, a causal relationship has …

Background Previous observational studies have shown an association between certain
cancers and the subsequent risk of prostate cancer (PCa). However, the causal relationship …