Targeting hypoxia-inducible factor-1α for the management of hepatocellular carcinoma

KN Huynh, S Rao, B Roth, T Bryan, DM Fernando… - Cancers, 2023 - mdpi.com
Simple Summary Hypoxia, or low oxygen levels within tumor tissue, presents a significant
challenge for the management of hepatocellular carcinoma (HCC). Hypoxic …

Hypoxia-induced ROS aggravate tumor progression through HIF-1α-SERPINE1 signaling in glioblastoma

L Zhang, Y Cao, X Guo, X Wang, X Han… - Journal of Zhejiang …, 2023 - Springer
Hypoxia, as an important hallmark of the tumor microenvironment, is a major cause of
oxidative stress and plays a central role in various malignant tumors, including glioblastoma …

Atomic force microscopy and high-resolution spectrophotometry for study of anoxemia and normoxemia in model experiment in vitro

E Kozlova, E Sherstyukova, V Sergunova… - International Journal of …, 2023 - mdpi.com
The oxygen content in the blood may decrease under the influence of various
physicochemical factors and different diseases. The state of hypoxemia is especially …

Differential Impact of intermittent vs. sustained hypoxia on HIF-1, VEGF and proliferation of HepG2 cells

M Minoves, F Hazane-Puch, G Moriondo… - International Journal of …, 2023 - mdpi.com
Obstructive sleep apnea (OSA) is an emerging risk factor for cancer occurrence and
progression, mainly mediated by intermittent hypoxia (IH). Systemic IH, a main landmark of …

[Retracted] Fluoride Exposure Suppresses Proliferation and Enhances Endoplasmic Reticulum Stress and Apoptosis Pathways in Hepatocytes by Downregulating …

Y Yu, L Li, W Yu, Z Guan - BioMed Research International, 2022 - Wiley Online Library
Objective. To explore the function and mechanism of Sirt‐1 in fluorine‐induced liver injury.
Method. Fluorosis rats were first established. The fluorine content, pathological structure …

Effect of novel AKT inhibitor Vevorisertib as single agent and in combination with Sorafenib on hepatocellular carcinoma in a cirrhotic rat model

K Kurma, A Zeybek Kuyucu, GS Roth, N Sturm… - International Journal of …, 2022 - mdpi.com
Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related mortality
worldwide. The AKT pathway is often activated in HCC cases, and a longer exposure to …

缺氧诱导的ROS 通过HIF-1α-SERPINE1 信号通路促进胶质母细胞瘤恶性进展

L ZHANG, Y CAO, X GUO, X WANG, X HAN… - Journal of Zhejiang …, 2023 - jzus.zju.edu.cn
缺氧作为肿瘤微环境的重要特征, 是氧化应激的主要原因, 在肿瘤(包括胶质母细胞瘤)
的恶性进展中发挥重要作用. 缺氧微环境中高水平活性氧(ROS) 促进胶质母细胞瘤进展的潜在 …

[PDF][PDF] Research Article Fluoride Exposure Suppresses Proliferation and Enhances Endoplasmic Reticulum Stress and Apoptosis Pathways in Hepatocytes by …

Y Yu, L Li, W Yu, Z Guan - 2022 - fluoridealert.org
Objective. To explore the function and mechanism of Sirt-1 in fluorine-induced liver injury.
Method. Fluorosis rats were first established. The fluorine content, pathological structure …

Синтез и антигипоксическая активность 2-арил-7, 7-диметил-5-оксо-5, 6, 7, 8-тетрагидрохинолин-4-карбоновых кислот и продуктов их реакции с …

КВ Намятова, СС Зыкова… - Разработка и …, 2023 - pharmjournal.ru
Аннотация Введение. Гипоксия представляет собой нарушение окислительных
процессов в тканях, возникающие при недостаточном поступлении в них кислорода или …

[引用][C] Fluoride Action Network

DQ Wu, Y Wu - Health