Cells undergo a major epigenome reconfiguration when reprogrammed to human induced
pluripotent stem cells (hiPS cells). However, the epigenomes of hiPS cells and human …

In toxicology, there is a strong push towards replacing animal experiments with alternative
methods, which include cell-based in vitro methods for the assessment of adverse health …

A plethora of human hepatocyte-based in vitro systems for toxicity testing has been
developed over the past few years. These systems are either directly derived from liver …

The liver plays an important role in xenobiotic metabolism and represents a primary target
for toxic substances. Many different in vitro cell models have been developed in the past …

Background & Aims Pluripotent stem cell (PSC)-derived hepatocyte-like cells (HLC) have
enormous potential as a replacement for primary hepatocytes in drug screening, toxicology …

Cancer-initiating cells (CIC) are the driving force in tumor progression. There is strong
evidence that CIC fulfill this task via exosomes (TEX), which modulate and reprogram …

In chronic liver diseases and hepatocellular carcinoma, the cells and extracellular matrix of
the liver undergo significant alteration in response to chronic injury. Recent literature has …

Much progress has been made in establishing strategies for differentiation of induced
human pluripotent stem cells (hiPSCs). However, differentiated hiPSCs are not yet routinely …

The development of regenerative medicine provides new options for the treatment of end-
stage liver diseases. Stem cells, such as bone marrow mesenchymal stem cells, embryonic …

Compared to other techniques, RNA sequencing (RNA-Seq) has the advantage of having
details of the expression abundance of all transcripts in a single run. In this study, we used …