Levetiracetam mechanisms of action: from molecules to systems

IJ Contreras-García, N Cárdenas-Rodríguez… - Pharmaceuticals, 2022 - mdpi.com
Epilepsy is a chronic disease that affects millions of people worldwide. Antiepileptic drugs
(AEDs) are used to control seizures. Even though parts of their mechanisms of action are …

Levetiracetam versus Oxcarbazepine as monotherapy in newly diagnosed focal epilepsy: A systematic review and meta‐analysis

S Kharel, R Ojha, S Khanal - Brain and Behavior, 2022 - Wiley Online Library
Objective To compare the efficacy and safety of Levetiracetam (LEV) and Oxcarbazepine
(OXC) as monotherapy for the treatment of newly diagnosed focal epilepsy. Methods We …

First‐line antiepileptic drug treatment in glioma patients with epilepsy: Levetiracetam vs valproic acid

PB van der Meer, L Dirven, M Fiocco, MJ Vos… - …, 2021 - Wiley Online Library
Objective This study aimed at estimating the cumulative incidence of antiepileptic drug
(AED) treatment failure of first‐line monotherapy levetiracetam vs valproic acid in glioma …

Experimental and molecular dynamics simulation study on the delivery of some common drugs by ZIF‐67, ZIF‐90, and ZIF‐8 zeolitic imidazolate frameworks

X Sun, M Keywanlu, R Tayebee - Applied Organometallic …, 2021 - Wiley Online Library
Anti‐seizures have been frequently used for a long time. Most of these antiepileptic drugs,
which are used on a daily basis, are central nervous system depressants, and their …

Cognitive profile in BECTS treated with levetiracetam: A 2-year follow-up

FF Operto, GMG Pastorino, R Mazza, M Roccella… - Epilepsy & Behavior, 2019 - Elsevier
Introduction Benign epilepsy with centrotemporal spikes (BECTS) is a common epileptic
syndrome in childhood, characterized by brief and infrequent partial motor seizures, with or …

Levetiracetam in genetic generalized epilepsy: a prospective unblinded active-controlled trial

N Tabrizi, A Zarvani, P Rezaei, H Cheraghmakani… - Epilepsy Research, 2019 - Elsevier
Purpose To compare the efficacy and tolerability of levetiracetam (LEV) versus valproate
(VPA) monotherapy in adults with genetic generalized tonic–clonic seizures alone (GTCS) …

Levetiracetam dosing for seizure prophylaxis in neurocritical care patients

A Hedges, MC Findlay, GE Davis, BM Wolfe… - Brain Injury, 2023 - Taylor & Francis
ABSTRACT Background/Objective Levetiracetam is used for seizure prophylaxis in patients
presenting with subarachnoid hemorrhage (SAH) or traumatic brain injury (TBI). We aim to …

Evaluation of embryonic teratogenic effects on fetal growth and development following prenatal exposure to different doses of levetiracetam in albino rats (rattus …

CK Kweri, J Kariuki, A Mwangi, JM Kanyoni… - Journal Of Agriculture …, 2023 - ojs.jkuat.ac.ke
The teratogenic effects of embryonic contact with different doses of levetiracetam, a second-
line anticonvulsant medicine on the growth and development of the fetus remain unclear …

Changes in the Dentate Gyrus Gene Expression Profile Induced by Levetiracetam Treatment in Rats with Mesial Temporal Lobe Epilepsy

V Diaz-Villegas, LA Pichardo-Macías… - International Journal of …, 2024 - mdpi.com
Temporal lobe epilepsy (TLE) is one of the most common forms of focal epilepsy.
Levetiracetam (LEV) is an antiepileptic drug whose mechanism of action at the genetic level …

[HTML][HTML] Cost-effectiveness of zonisamide versus levetiracetam in newly diagnosed focal onset epilepsy in Serbia

I Mikulić, R Likić, SM Janković - Value in health regional issues, 2022 - Elsevier
Objectives When choosing initial therapy for epilepsy, the decision should be supported by
studies that include both treatment outcome and costs. This is especially important for …