Overall, asthma mortality rates have declined dramatically in the last 30 years, due to
improved diagnosis and to better treatment, particularly in the 1990s following the more …

Asthma is a common heterogeneous disease with a complex pathophysiology that carries a
significant mortality rate and high morbidity. Current therapies based on inhaled …

Background Elevated sputum eosinophil counts predict asthma exacerbations and
responsiveness to inhaled corticosteroids but are impractical to measure in primary care. We …

Background Monitoring sputum eosinophils in asthma predicts exacerbations and improves
management of asthma. Thus far, blood eosinophils and FENO show contradictory results in …

Background Clinical cluster analysis from the Severe Asthma Research Program (SARP)
identified 5 asthma subphenotypes that represent the severity spectrum of early-onset …

Background: The fractional exhaled nitric oxide (FeNO) test is a point-of-care test that is
used in the assessment of asthma. Objective: To provide evidence-based clinical guidance …

Rationale: Eosinophilic asthma is a phenotype of asthma characterized by the persistence of
eosinophils in the airways. IL-5 is involved in the activation and survival of eosinophils …

Background: The assessment of asthma control is pivotal to the evaluation of treatment
response in individuals and in clinical trials. Previously, asthma control, severity, and …

Background Exacerbations of asthma are associated with substantial morbidity and mortality
and with considerable use of health care resources. Preventing exacerbations remains an …

Rationale: Airway eosinophilia is typical of asthma, and many controller treatments target
eosinophilic disease. Asthma is clinically heterogeneous, however, and a subgroup of …