Asthma progression and mortality: the role of inhaled corticosteroids
Overall, asthma mortality rates have declined dramatically in the last 30 years, due to
improved diagnosis and to better treatment, particularly in the 1990s following the more …
improved diagnosis and to better treatment, particularly in the 1990s following the more …
Asthma phenotyping: a necessity for improved therapeutic precision and new targeted therapies
KF Chung - Journal of internal medicine, 2016 - Wiley Online Library
Asthma is a common heterogeneous disease with a complex pathophysiology that carries a
significant mortality rate and high morbidity. Current therapies based on inhaled …
significant mortality rate and high morbidity. Current therapies based on inhaled …
Blood eosinophil count and prospective annual asthma disease burden: a UK cohort study
DB Price, A Rigazio, JD Campbell… - The lancet Respiratory …, 2015 - thelancet.com
Background Elevated sputum eosinophil counts predict asthma exacerbations and
responsiveness to inhaled corticosteroids but are impractical to measure in primary care. We …
responsiveness to inhaled corticosteroids but are impractical to measure in primary care. We …
External validation of blood eosinophils, FENO and serum periostin as surrogates for sputum eosinophils in asthma
AH Wagener, SB de Nijs, R Lutter, AR Sousa… - Thorax, 2015 - thorax.bmj.com
Background Monitoring sputum eosinophils in asthma predicts exacerbations and improves
management of asthma. Thus far, blood eosinophils and FENO show contradictory results in …
management of asthma. Thus far, blood eosinophils and FENO show contradictory results in …
Sputum neutrophil counts are associated with more severe asthma phenotypes using cluster analysis
WC Moore, AT Hastie, X Li, H Li, WW Busse… - Journal of Allergy and …, 2014 - Elsevier
Background Clinical cluster analysis from the Severe Asthma Research Program (SARP)
identified 5 asthma subphenotypes that represent the severity spectrum of early-onset …
identified 5 asthma subphenotypes that represent the severity spectrum of early-onset …
Use of fractional exhaled nitric oxide to guide the treatment of asthma: an official American Thoracic Society clinical practice guideline
SB Khatri, JM Iaccarino, A Barochia… - American journal of …, 2021 - atsjournals.org
Background: The fractional exhaled nitric oxide (FeNO) test is a point-of-care test that is
used in the assessment of asthma. Objective: To provide evidence-based clinical guidance …
used in the assessment of asthma. Objective: To provide evidence-based clinical guidance …
Reslizumab for poorly controlled, eosinophilic asthma: a randomized, placebo-controlled study
M Castro, S Mathur, F Hargreave, LP Boulet… - American journal of …, 2011 - atsjournals.org
Rationale: Eosinophilic asthma is a phenotype of asthma characterized by the persistence of
eosinophils in the airways. IL-5 is involved in the activation and survival of eosinophils …
eosinophils in the airways. IL-5 is involved in the activation and survival of eosinophils …
An official American Thoracic Society/European Respiratory Society statement: asthma control and exacerbations: standardizing endpoints for clinical asthma trials …
HK Reddel, DR Taylor, ED Bateman… - American journal of …, 2009 - atsjournals.org
Background: The assessment of asthma control is pivotal to the evaluation of treatment
response in individuals and in clinical trials. Previously, asthma control, severity, and …
response in individuals and in clinical trials. Previously, asthma control, severity, and …
Mepolizumab and exacerbations of refractory eosinophilic asthma
P Haldar, CE Brightling, B Hargadon… - New England journal …, 2009 - Mass Medical Soc
Background Exacerbations of asthma are associated with substantial morbidity and mortality
and with considerable use of health care resources. Preventing exacerbations remains an …
and with considerable use of health care resources. Preventing exacerbations remains an …
A large subgroup of mild-to-moderate asthma is persistently noneosinophilic
KW McGrath, N Icitovic, HA Boushey… - American journal of …, 2012 - atsjournals.org
Rationale: Airway eosinophilia is typical of asthma, and many controller treatments target
eosinophilic disease. Asthma is clinically heterogeneous, however, and a subgroup of …
eosinophilic disease. Asthma is clinically heterogeneous, however, and a subgroup of …