The centromere performs a universally conserved function, to accurately partition genetic
information upon cell division. Yet, centromeres are among the most rapidly evolving …

Kinetochores are molecular machines that power chromosome segregation during the
mitotic and meiotic cell divisions of all eukaryotes. Aristotle explains how we think we have …

Our understanding of the structure and function of mitotic chromosomes has come a long
way since these iconic objects were first recognized more than 140 years ago, though many …

In contrast to well-studied fungal and animal cells, plant cells assemble bipolar spindles that
exhibit a great deal of plasticity in the absence of structurally defined microtubule-organizing …

Alzheimer's disease (AD) is characterized by the presence of β-amyloid plaques (Aβ) and
neurofibrillary tangles (NFTs) in the brain. The prevalence of the disease is increasing and is …

Centromere protein U (CENPU), a centromere-binding protein required for cellular mitosis,
has been reported to be closely associated with carcinogenesis in multiple malignancies; …

The extracellular matrix (ECM) is a network of structural proteins, glycoproteins and
proteoglycans that assists independent cells in aggregating and forming highly organized …

In most animal cell types, the interphase nucleus is largely disassembled during mitotic
entry. The nuclear envelope breaks down and chromosomes are compacted into separated …

Asymmetric cell division produces two cells that are genetically identical but each have
distinctly different cell fates. During this process, epigenetic mechanisms play an important …

Epigenetic dysregulation is an important contributor to carcinogenesis. This is not surprising,
as chromatin—genomic DNA organized around structural histone scaffolding—serves as the …