Since the first identification of renin by Tigerstedt and Bergmann in 1898, the renin-
angiotensin system (RAS) has been extensively studied. The current view of the system is …

Elevations in intrarenal angiotensin II (Ang II) cause reductions in renal function and sodium
excretion that contribute to progressive hypertension and lead to renal and vascular injury …

In recent years, the use of genetically altered mice as models of complex human disease
has revolutionized biomedical research into the genetics of disease pathogenesis and …

Experimental analysis of the effects of individual components of complex mammalian
systems is frequently impeded by compensatory adjustments that animals make to achieve …

Hypertension is a polygenic and multifactorial disease that has received a great deal of
interest because of its high incidence not only in the West but also in developing countries. It …

In this study the authors sought to improve the technique of isolating and culturing murine
aortic endothelial cells (MAECs) for future use in studying endothelium-specific roles in …

The objective of the paper is to determine the influence of IGF-1 deletion on renal
sympathetic nerve activity (RSNA), left ventricular dysfunction, and renal function in …

Atherosclerosis occurs preferentially at branches and curves in arteries exposed to
disturbed flow while sparing straight portions of arteries exposed to undisturbed flow. In vivo …

ABSTRACT Almahroug, Najat Khalifa. MS, Department of Pharmacology & Toxicology,
Wright State University, 2013. Chronic Swim Stress Attenuates Endocrine Response and …

During a single bout of aerobic exercise, blood flow is shunted to exercising tissues while
blood flow is maintained or reduced to less metabolically active areas (ie splanchnic area …