Redox state is a term used widely in the research field of free radicals and oxidative stress.
Unfortunately, it is used as a general term referring to relative changes that are not well …

Resistance to anticancer drugs is a complex process that results from alterations in drug
targets; development of alternative pathways for growth activation; changes in cellular …

The platinum drugs cisplatin, carboplatin, and oxaliplatin are highly utilized in the clinic and
as a consequence are extensively studied in the laboratory setting. In this study, we …

Cisplatin is a highly effective antitumor agent whose clinical application is limited by the
inherent nephrotoxicity. The current measures of nephroprotection used in patients receiving …

The platinum drugs represent a unique and important class of antitumor agents. The clinical
development of the neutral, square planar, coordination complex cis …

Cisplatin is one of the most widely used chemotherapeutic agents for the treatment of
several human malignancies. The efficacy of cisplatin is dose dependent, but the significant …

Ototoxicity refers to damage of inner ear structures (ie, the cochlea and vestibule) and their
function (hearing and balance) following exposure to specific in-hospital medications (ie …

25 years after the first approval of cisplatin in the clinic against a number of cancer diseases,
cisplatin and related compounds continue to be among the most efficient anticancer drugs …

Thirty years after the onset of the first clinical studies with cisplatin, the development of
antineoplastic platinum drugs continues to be a productive field of research. This article …

A series of heteroleptic square-planar Pt and Pd complexes with bis (diisopropylphenyl)
iminoacenaphtene (dpp-Bian) and Cl, 1, 3-dithia-2-thione-4, 5-dithiolate (dmit), or 1, 3-dithia …