Despite decades of bile acid research, diverse biological roles for bile acids have been
discovered recently due to developments in understanding the human microbiota. As …

Bile acids play key roles in gut metabolism, cell signaling, and microbiome composition.
While the liver is responsible for the production of primary bile acids, microbes in the gut …

The gut microbiota is responsible for recovering energy from food, providing hosts with
vitamins, and providing a barrier function against exogenous pathogens. In addition, it is …

Farnesoid X receptor (FXR) is a ligand-activated transcription factor involved in the control of
bile acid (BA) synthesis and enterohepatic circulation. FXR can influence glucose and lipid …

Bile acids are soluble derivatives of cholesterol produced in the liver that subsequently
undergo bacterial transformation yielding a diverse array of metabolites. The bulk of bile …

Food is a primordial need for our survival and well-being. However, diet is not only essential
to maintain human growth, reproduction, and health, but it also modulates and supports the …

Emerging evidence points to a strong association between the gut microbiota and the risk,
development and progression of gastrointestinal cancers such as colorectal cancer (CRC) …

Obesity is a mostly preventable diet-related disease and currently a major challenge for
human populations worldwide. Obesity is a major risk factor for diseases such as type 2 …

Secondary bile acids (BAs) and short chain fatty acids (SCFAs), two major types of bacterial
metabolites in the colon, cause opposing effects on colonic inflammation at chronically high …

The microbiome has an important role in human health. Changes in the microbiota can
confer resistance to or promote infection by pathogenic bacteria. Antibiotics have a profound …