The functional interplay between the HIF pathway and the ubiquitin system–more than a one-way road
J Günter, A Ruiz-Serrano, C Pickel, RH Wenger… - Experimental cell …, 2017 - Elsevier
The hypoxia inducible factor (HIF) pathway and the ubiquitin system represent major cellular
processes that are involved in the regulation of a plethora of cellular signaling pathways and …
processes that are involved in the regulation of a plethora of cellular signaling pathways and …
[HTML][HTML] The oxygen-generating calcium peroxide-modified magnetic nanoparticles attenuate hypoxia-induced chemoresistance in triple-negative breast cancer
FY Cheng, CH Chan, BJ Wang, YL Yeh, YJ Wang… - Cancers, 2021 - mdpi.com
Simple Summary Tumor hypoxia is known to increase the resistance of cancer cells to
chemotherapy. Triple-negative breast cancer (TNBC) is the most aggressive subtype of …
chemotherapy. Triple-negative breast cancer (TNBC) is the most aggressive subtype of …
Ubiquitin carboxyl‐terminal hydrolase L1 promotes hypoxia‐inducible factor 1‐dependent tumor cell malignancy in spheroid models
X Li, A Hattori, S Takahashi, Y Goto, H Harada… - Cancer …, 2020 - Wiley Online Library
Abstract Hypoxia‐inducible factor 1 (HIF‐1) is a critical heterodimeric transcription factor for
tumor malignancy. Recently, ubiquitin carboxyl‐terminal hydrolase L1 (UCHL1) has been …
tumor malignancy. Recently, ubiquitin carboxyl‐terminal hydrolase L1 (UCHL1) has been …
Isoliquiritigenin inhibits proliferation and induces apoptosis via alleviating hypoxia and reducing glycolysis in mouse melanoma B16F10 cells
Y Wang, J Ma, X Yan, X Chen, L Si… - Recent patents on …, 2016 - ingentaconnect.com
Background: Isoliquiritigenin (ISL) is a licorice chalcone. According to CN104758274,
CN101658513 and US009089546, it is claimed that ISL has anti-inflammatory, anti …
CN101658513 and US009089546, it is claimed that ISL has anti-inflammatory, anti …
[HTML][HTML] Splice variants of cytosolic polyadenylation element–binding protein 2 (CPEB2) differentially regulate pathways linked to cancer metastasis
JT DeLigio, G Lin, CE Chalfant, MA Park - Journal of Biological Chemistry, 2017 - ASBMB
The translational regulator cytosolic polyadenylation element–binding protein 2 (CPEB2)
has two isoforms, CPEB2A and CPEB2B, derived by alternative splicing of RNA into a …
has two isoforms, CPEB2A and CPEB2B, derived by alternative splicing of RNA into a …
[HTML][HTML] Comparative microRNA transcriptomes in domestic goats reveal acclimatization to high altitude
High-altitude acclimatization is a representative example of vertebrates' acclimatization to
harsh and extreme environments. Previous studies reported sufficient evidence for a …
harsh and extreme environments. Previous studies reported sufficient evidence for a …
Responses of Porcupine and Wntless proteins to oxidative, hypoxic and endoplasmic reticulum stresses
R Mohamed, C Kennedy, WG Willmore - Cellular Signalling, 2021 - Elsevier
Abstract The WNT (Wingless and Int-1) proteins play a role in stem cell development and
cell differentiation. Mutations in the WNT proteins lead to the development of various …
cell differentiation. Mutations in the WNT proteins lead to the development of various …
HAHmiR. DB: a server platform for high-altitude human miRNA–gene coregulatory networks and associated regulatory circuits
P Khurana, A Gupta, R Sugadev, YK Sharma… - Database, 2020 - academic.oup.com
Around 140 million people live in high-altitude (HA) conditions! and even a larger number
visit such places for tourism, adventure-seeking or sports training. Rapid ascent to HA can …
visit such places for tourism, adventure-seeking or sports training. Rapid ascent to HA can …
Transcriptome analysis reveals hub genes in the hepatopancreas of Exopalaemon carinicauda in response to hypoxia and reoxygenation
W Shi, P Wang, R Hu, X Wan, H Shen, H Li… - Aquaculture …, 2021 - Springer
Hypoxia is a common stressor in shrimp, but the molecular mechanisms underlying the
adaptation of the ridgetail white prawn, Exopalaemon carinicauda, to hypoxia and …
adaptation of the ridgetail white prawn, Exopalaemon carinicauda, to hypoxia and …
[HTML][HTML] ΔNp73 enhances HIF-1α protein stability through repression of the ECV complex
M Stantic, J Wolfsberger, HAM Sakil, MT Wilhelm - Oncogene, 2018 - nature.com
Cellular responses to low oxygen conditions are mainly regulated by the Hypoxia-inducible
factors (HIFs). Induction of HIF-1α in tumor cells activates the angiogenic switch and allows …
factors (HIFs). Induction of HIF-1α in tumor cells activates the angiogenic switch and allows …