Alterations of DNA methylation and transcription of microRNAs (miRNAs) are very stable
phenomena in tissues and body fluids and suitable for sensitive detection. These …

Lynch syndrome, familial adenomatous polyposis, and Mut Y homolog (MYH)-associated
polyposis are three major known types of inherited colorectal cancer, which accounts for up …

Epigenetic silencing by hypermethylation of CpGs represents a mechanism of inactivation of
tumor suppressors. Here we report on the cloning of a novel candidate tumor suppressor …

Background Hepatocellular carcinoma (HCC) is one of the most common causes of cancer-
related mortality in the world; however, the molecular mechanisms leading to hepatocyte …

The hMLH1 gene plays an essential role in DNA repair. Methylation of the hMLH1 gene is
common in many types of cancer and can lead to the loss of hMLH1 expression. However …

Background/Aims: Human mutL homolog 1 (MLH1) promoter methylation was reported in
gastric cancer (GC). This study determined the clinicopathological, prognostic, and …

变性高效液相色谱(DHPLC) 是一种高通量筛选DNA 序列变异的新技术, 从该仪器设备的组成,
工作原理, 基本操作方法, 主要技术特点等作一综述, 并对其在基因组领域的应用如SNP 分析 …

Polymorphisms in DNA repair genes may be associated with differences in repair capacity of
DNA damage and may thereby influence an individual's susceptibility to lung cancer. We …

DNA mismatch repair, known as a fundamentally biological pathway, plays key roles in
maintaining genomic stability, eliminating mismatch bases and preventing both mutagenesis …

To elucidate the veritable relationship between three hMLH1 polymorphisms (rs1800734,
rs1799977, rs63750447) and cancer risk, we performed this meta-analysis based on overall …