Current trends in toxicity assessment of herbal medicines: A narrative review

A Jităreanu, A Trifan, M Vieriu, IC Caba, I Mârțu… - Processes, 2022 - mdpi.com
Even in modern times, the popularity level of medicinal plants and herbal medicines in
therapy is still high. The World Health Organization estimates that 80% of the population in …

High throughput microscopy and single cell phenotypic image-based analysis in toxicology and drug discovery

S Fabio, KS Pankaj, S Kazem, M Michela… - Biochemical …, 2023 - Elsevier
Measuring single cell responses to the universe of chemicals (drugs, natural products,
environmental toxicants etc.) is of paramount importance to human health as phenotypic …

Comparative analysis between 2D and 3D colorectal cancer culture models for insights into cellular morphological and transcriptomic variations

ZN Abbas, AZ Al-Saffar, SM Jasim, GM Sulaiman - Scientific Reports, 2023 - nature.com
Drug development is a time-consuming and expensive process, given the low success rate
of clinical trials. Now, anticancer drug developments have shifted to three-dimensional (3D) …

Droplets microfluidics platform—A tool for single cell research

B Li, X Ma, J Cheng, T Tian, J Guo, Y Wang… - … in Bioengineering and …, 2023 - frontiersin.org
Cells are the most basic structural and functional units of living organisms. Studies of cell
growth, differentiation, apoptosis, and cell-cell interactions can help scientists understand …

Metformin hydrochloride significantly inhibits rotavirus infection in Caco2 cell line, intestinal organoids, and mice

R Zhang, C Feng, D Luo, R Zhao, PR Kannan, Y Yin… - Pharmaceuticals, 2023 - mdpi.com
Rotavirus is one of the main pathogens that causes severe diarrhea in children under the
age of 5, primarily infecting the enterocytes of the small intestine. Currently, there are no …

Infantile hemangioma models: is the needle in a haystack?

M Kong, Y Li, K Wang, S Zhang, Y Ji - Journal of translational medicine, 2023 - Springer
Infantile hemangioma (IH) is the most prevalent benign vascular tumor in infants, with
distinct disease stages and durations. Despite the fact that the majority of IHs can regress …

New frontiers in three-dimensional culture platforms to improve diabetes research

S Mohandas, V Gayatri, K Kumaran, V Gopinath… - Pharmaceutics, 2023 - mdpi.com
Diabetes mellitus is associated with defects in islet β-cell functioning and consequent
hyperglycemia resulting in multi-organ damage. Physiologically relevant models that mimic …

[HTML][HTML] Inner ear organoids: recent progress and potential applications

Y Lou, Y Liu, M Wu, G Jia, M Xia, W Li - Fundamental Research, 2023 - Elsevier
The inner ear is one of the most complicated structures that harbor organs for the perception
of sound and balance, which is deep in the temporal bone and challenging to operate …

Generation of a novel three-dimensional scaffold-based model of the bovine endometrium

MC Díez, S Przyborski, A Del Cerro… - Veterinary Research …, 2023 - Springer
Bovine in vitro endometrial models that resemble tissue function in vivo are needed to study
infertility, long-term uterine alterations induced by pathogens and impact of endocrine …

Enhanced Biomimetics of Three-Dimensional Osteosarcoma Models: A Scoping Review

V Sandhu, D Bakkalci, S Wei, U Cheema - Cancers, 2023 - mdpi.com
Simple Summary This review explores various studies to understand how 3D cell cultures
mimic real tumour conditions and respond to anticancer drugs. This study focuses on …