Hyperpolarization is a technique that can increase nuclear spin polarization with the
corresponding gains in nuclear magnetic resonance (NMR) signals by 4–8 orders of …

The use of pulmonary MRI in a clinical setting has historically been limited. Whilst CT
remains the gold-standard for structural lung imaging in many clinical indications, technical …

Hyperpolarized (HP) 129Xe MRI uniquely images pulmonary ventilation, gas exchange, and
terminal airway morphology rapidly and safely, providing novel information not possible …

Structural and functional defects within the lungs of children with cystic fibrosis (CF) are
detectable soon after birth and progress throughout preschool years often without overt …

Rationale and Objectives Phase resolved functional lung (PREFUL) magnetic resonance
imaging (MRI) is a free-breathing 1 H-based technique that produces maps of fractional …

With an increasing number of patients with cystic fibrosis (CF) receiving highly effective
CFTR (cystic fibrosis transmembrane regulator protein) modulator therapy, particularly at a …

Background Multiple‐breath washout (MBW) 129Xe MRI (MBW Xe‐MRI) is a promising
technique for following pediatric cystic fibrosis (CF) lung disease progression. However, its …

Pathophysiologic changes in lung diseases are often accompanied by changes in
ventilation and gas exchange. Comprehensive evaluation of lung function cannot be …

Purpose In this study, we compared hyperpolarized 3 He and 129 Xe images from patients
with cystic fibrosis using two commonly applied magnetic resonance sequences, standard …

Despite evidence showing an improvement in nutritional outcomes following diagnosis by
newborn screening (NBS) for cystic fibrosis (CF), the impact on pulmonary outcomes has …