[HTML][HTML] Pseudomonas aeruginosa: pathogenesis, virulence factors, antibiotic resistance, interaction with host, technology advances and emerging therapeutics

S Qin, W Xiao, C Zhou, Q Pu, X Deng, L Lan… - Signal transduction and …, 2022 - nature.com
Pseudomonas aeruginosa (P. aeruginosa) is a Gram-negative opportunistic pathogen that
infects patients with cystic fibrosis, burn wounds, immunodeficiency, chronic obstructive …

[HTML][HTML] CRISPR-based diagnostics

MM Kaminski, OO Abudayyeh, JS Gootenberg… - Nature Biomedical …, 2021 - nature.com
The accurate and timely diagnosis of disease is a prerequisite for efficient therapeutic
intervention and epidemiological surveillance. Diagnostics based on the detection of nucleic …

Bacterial defences: mechanisms, evolution and antimicrobial resistance

WPJ Smith, BR Wucher, CD Nadell… - Nature Reviews …, 2023 - nature.com
Throughout their evolutionary history, bacteria have faced diverse threats from other
microorganisms, including competing bacteria, bacteriophages and predators. In response …

[HTML][HTML] Biofilms as promoters of bacterial antibiotic resistance and tolerance

C Uruén, G Chopo-Escuin, J Tommassen… - Antibiotics, 2020 - mdpi.com
Multidrug resistant bacteria are a global threat for human and animal health. However, they
are only part of the problem of antibiotic failure. Another bacterial strategy that contributes to …

Beyond horizontal gene transfer: the role of plasmids in bacterial evolution

J Rodríguez-Beltrán, J DelaFuente… - Nature Reviews …, 2021 - nature.com
Plasmids have a key role in bacterial ecology and evolution because they mobilize
accessory genes by horizontal gene transfer. However, recent studies have revealed that …

Clinically relevant mutations in core metabolic genes confer antibiotic resistance

AJ Lopatkin, SC Bening, AL Manson, JM Stokes… - Science, 2021 - science.org
Although metabolism plays an active role in antibiotic lethality, antibiotic resistance is
generally associated with drug target modification, enzymatic inactivation, and/or transport …

Understanding human health risks caused by antibiotic resistant bacteria (ARB) and antibiotic resistance genes (ARG) in water environments: Current knowledge and …

M Amarasiri, D Sano, S Suzuki - Critical Reviews in Environmental …, 2020 - Taylor & Francis
Aquatic environments are identified as an ideal setting for acquisition and dissemination of
antibiotic resistance, and human exposure to antibiotic resistant bacteria (ARB) and …

Importance of antibiotic residues in animal food

M Bacanlı, N Başaran - Food and Chemical Toxicology, 2019 - Elsevier
Veterinary medicines, especially antibiotics, are among the most important components
related to animal feed production. Generally, the main use of antibiotics in animals is for the …

[HTML][HTML] Structure, genetics and worldwide spread of New Delhi metallo-β-lactamase (NDM): a threat to public health

AU Khan, L Maryam, R Zarrilli - BMC microbiology, 2017 - Springer
Background The emergence of carbapenemase producing bacteria, especially New Delhi
metallo-β-lactamase (NDM-1) and its variants, worldwide, has raised amajor public health …

Both silver ions and silver nanoparticles facilitate the horizontal transfer of plasmid-mediated antibiotic resistance genes

J Lu, Y Wang, M Jin, Z Yuan, P Bond, J Guo - Water research, 2020 - Elsevier
Antibiotic resistance in bacteria is a growing threat to global human health. Horizontal gene
transfer (HGT) of antibiotic resistance genes (ARGs) is recognized as the primary contributor …