Perindopril: a review of its pharmacological properties and therapeutic use in cardiovascular disorders

PA Todd, A Fitton - Drugs, 1991 - Springer
Synopsis Perindopril is a long acting angiotensin converting enzyme (ACE) inhibitor, which
displays similar pharmacodynamic properties to other agents in this class. In common with …

Newer ACE inhibitors: a look at the future

A Salvetti - Drugs, 1990 - Springer
Available information indicates that about 78 new molecules belonging to the class of
angiotensin converting enzyme (ACE) inhibitors are under investigation, and that at least 11 …

Angiotensin (1–7) in the spontaneously hypertensive rat

K Kohara, K Bridget, CM Ferrario - Peptides, 1993 - Elsevier
We profiled the concentrations of angiotensin I (Ang I), angiotensin II (Ang II), and
angiotensin (1–7)[Ang (1–7)] by the combination of radioimmunoassay and high …

Importance of the renin-angiotensin-aldosterone system (RAS) in the physiology and pathology of hypertension: an overview

CM Ferrario - Drugs, 1990 - Springer
Current leading theories of the mechanisms of essential hypertension include the
participation of the renin-angiotensin-aldosterone system (RAS). Recent advances provide …

Bradykinin B2 Receptor Antagonism Attenuates Blood Pressure Response to Acute Angiotensin-Converting Enzyme Inhibition in Normal Men

IB Squire, KPJ O'Kane, N Anderson, JL Reid - Hypertension, 2000 - Am Heart Assoc
The physiological effects of angiotensin-converting enzyme (ACE) inhibition may be in part
mediated by bradykinin. We investigated the effect of coadministration of the specific …

The basis and evidence of a role for the ovarian renin-angiotensin system in health and disease

G Nemtth, JR Pepperell, Y Yamada, A Palumbo… - The Journal of the …, 1994 - Springer
Objective We reviewed the evidence for an intrinsic ovarian renin-angiotensin system
(OVRAS), highlighting potential diverse signaling in this system through different bioactive …

Peripheral vs. central blockade of the renin-angiotensin system in spontaneously hypertensive rats: comparison of novel AT1 receptor antagonist TCV-116 with …

K Kohara, H Mikami, N Okuda, T Ogihara - Hypertension Research, 1993 - jstage.jst.go.jp
In the present study, we evaluated the hemodynamic and metabolic profiles derived from
oral administration of the angiotensin converting enzyme inhibitor, delapril 50 mg/kg/day …

A novel angiotensin analog with subnanomolar affinity for angiotensin-converting enzyme

LT Krebs, JM Hanesworth, MF Sardinia… - … of Pharmacology and …, 2000 - ASPET
This study demonstrates that a novel angiotensin I analog, angiotensinogen 3–11 (Lys11),
possesses a high affinity for angiotensin-converting enzyme (ACE), which is substantially …

Effect of chronic treatment with enalapril on glucose tolerance and serum insulin in non-insulin-resistant Japanese patients with essential hypertension

T Baba, T Kodama, T Ishizaki - European journal of clinical pharmacology, 1993 - Springer
The effect of enalapril, an angiotensin converting enzyme inhibitor, on glucose tolerance
and serum insulin response to a glucose load has been evaluated in 8 non-obese patients …

Captopril test in children with reflux nephropathy

RMA Hamed, G Ellis, M Levy, GA McLorie… - Pediatric Nephrology, 1992 - Springer
We studied the plasma renin activity (PRA) and blood pressure (BP) responses to a single
oral dose of captopril in children with renal scarring due to vesicoureteral reflux. The test …