TET-mediated active DNA demethylation: mechanism, function and beyond
In mammals, DNA methylation in the form of 5-methylcytosine (5mC) can be actively
reversed to unmodified cytosine (C) through TET dioxygenase-mediated oxidation of 5mC to …
reversed to unmodified cytosine (C) through TET dioxygenase-mediated oxidation of 5mC to …
DNA methylation in mammals
E Li, Y Zhang - Cold Spring Harbor perspectives in …, 2014 - cshperspectives.cshlp.org
DNA methylation is one of the best characterized epigenetic modifications. In mammals it is
involved in various biological processes including the silencing of transposable elements …
involved in various biological processes including the silencing of transposable elements …
Transgenerational inheritance: how impacts to the epigenetic and genetic information of parents affect offspring health
BACKGROUND A defining feature of sexual reproduction is the transmission of genomic
information from both parents to the offspring. There is now compelling evidence that the …
information from both parents to the offspring. There is now compelling evidence that the …
A unique regulatory phase of DNA methylation in the early mammalian embryo
DNA methylation is highly dynamic during mammalian embryogenesis. It is broadly
accepted that the paternal genome is actively depleted of 5-methylcytosine at fertilization …
accepted that the paternal genome is actively depleted of 5-methylcytosine at fertilization …
Active and passive demethylation of male and female pronuclear DNA in the mammalian zygote
The epigenomes of mammalian sperm and oocytes, characterized by gamete-specific 5-
methylcytosine (5mC) patterns, are reprogrammed during early embryogenesis to establish …
methylcytosine (5mC) patterns, are reprogrammed during early embryogenesis to establish …
DNA methylation patterns and epigenetic memory
A Bird - Genes & development, 2002 - genesdev.cshlp.org
The character of a cell is defined by its constituent proteins, which are the result of specific
patterns of gene expression. Crucial determinants of gene expression patterns are DNA …
patterns of gene expression. Crucial determinants of gene expression patterns are DNA …
Active DNA demethylation: many roads lead to Rome
SC Wu, Y Zhang - Nature reviews Molecular cell biology, 2010 - nature.com
DNA methylation is one of the best-characterized epigenetic modifications and has been
implicated in numerous biological processes, including transposable element silencing …
implicated in numerous biological processes, including transposable element silencing …
[HTML][HTML] DNA demethylation dynamics
N Bhutani, DM Burns, HM Blau - Cell, 2011 - cell.com
The discovery of cytosine hydroxymethylation (5hmC) suggested a simple means of
demethylating DNA and activating genes. Further experiments, however, unearthed an …
demethylating DNA and activating genes. Further experiments, however, unearthed an …
Mechanisms and functions of Tet protein-mediated 5-methylcytosine oxidation
Ten-eleven translocation 1–3 (Tet1–3) proteins have recently been discovered in
mammalian cells to be members of a family of DNA hydroxylases that possess enzymatic …
mammalian cells to be members of a family of DNA hydroxylases that possess enzymatic …
Epigenetic reprogramming in mammalian development
DNA methylation is a major epigenetic modification of the genome that regulates crucial
aspects of its function. Genomic methylation patterns in somatic differentiated cells are …
aspects of its function. Genomic methylation patterns in somatic differentiated cells are …