Treatment of animal African trypanosomiasis (AAT) requires urgent need for safe, potent and
affordable drugs and this has necessitated this study. We investigated the trypanocidal …

Carbocyclic nucleosides have long played a role in antiviral, antiparasitic, and antibacterial
therapies. Recent results from our laboratories from two structurally related scaffolds have …

The 6‐oxopurine phosphoribosyltransferases (PRT s) are drug targets for the treatment of
parasitic diseases. This is due to the fact that parasites are auxotrophic for the 6‐oxopurine …

The transport of nucleobases and nucleosides in protozoan parasites is known to be
performed by Equilibrative Nucleoside Transporter (ENT) family members, including the …

Carbocyclic nucleoside analogues have a distinguished history as anti-infectious agents,
including key antiviral agents. Toxicity was initially a concern but this was reduced by the …

Among the scarce validated drug targets against Chagas disease (CD), caused by
Trypanosoma cruzi, the parasite's nucleoside salvage system has recently attracted …

Tsetse flies are major arthropod vectors of trypanosomes that cause debilitating African
animal trypanosomiasis. The emergence of drug-resistant trypanosomes is a common …

Current chemotherapy against African sleeping sickness, a disease caused by the
protozoan parasite Trypanosoma brucei, is limited by toxicity, inefficacy, and drug …

Protozoa and helminths have by far the greatest impact in terms of morbidity worldwide. The
status of protozoa and helminths control, both in human and veterinary medicine, is …

Kinetoplastid parasites such as Trypanosoma brucei, Trypanosoma cruzi, and Leishmania
species rely upon their insect and vertebrate hosts to provide a plethora of nutrients …