[HTML][HTML] Curcumin, inflammation, and neurological disorders: How are they linked?

P Garodia, M Hegde, AB Kunnumakkara… - Integrative Medicine …, 2023 - Elsevier
Background: Despite the extensive research in recent years, the current treatment modalities
for neurological disorders are suboptimal. Curcumin, a polyphenol majorly found in …

Dietary polyphenols, microbiome, and multiple sclerosis: From molecular anti-inflammatory and neuroprotective mechanisms to clinical evidence

G La Rosa, MS Lonardo, N Cacciapuoti… - International Journal of …, 2023 - mdpi.com
Multiple sclerosis (MS) is a multifactorial, immune-mediated disease caused by complex
gene-environment interactions. Dietary factors modulating the inflammatory status through …

[HTML][HTML] Curcumin as a regulator of Th17 cells: Unveiling the mechanisms

E Ghoushi, M Poudineh, N Parsamanesh… - Food Chemistry …, 2024 - Elsevier
Curcumin, a polyphenol natural product derived from turmeric, possesses diverse
pharmacological effects due to its interactions with various cells and molecules. Recent …

Neuroprotective effect of curcumin against experimental autoimmune encephalomyelitis-induced cognitive and physical impairments in mice: an insight into the role of …

MA Sadek, MA Rabie, NS El Sayed, HM Sayed… - …, 2024 - Springer
Multiple sclerosis (MS) is an incurable chronic neurodegenerative disease where
autoimmunity, oxidative stress, and neuroinflammation collaboration predispose myelin …

Curcumin's spice-infused therapeutic promise: disease severity alleviation in a mouse model of multiple sclerosis via modulation of immune responses

Z Amiri, S Jalili, M Tarahomi, M Eslami… - Molecular Biology …, 2023 - Springer
Background Multiple sclerosis (MS) is an autoimmune central nervous system (CNS)
disorder indicated by demyelination, chronic inflammation, and neuronal destruction …

Trends in Gliosis in Obesity, and the Role of Antioxidants as a Therapeutic Alternative

C Bandala, N Cárdenas-Rodríguez, S Reyes-Long… - Antioxidants, 2022 - mdpi.com
Obesity remains a global health problem. Chronic low-grade inflammation in this pathology
has been related to comorbidities such as cognitive alterations that, in the long term, can …

Nanocarrier-mediated curcumin delivery: An adjuvant strategy for CNS disease treatment

S Godse, L Zhou, S Sakshi, B Singla… - Experimental …, 2023 - journals.sagepub.com
Neurological disorders are a major global challenge, which counts for a substantial slice of
disease burden around the globe. In these, the challenging landscape of central nervous …

Amelioration of the brain structural connectivity is accompanied with changes of gut microbiota in a tuberous sclerosis complex mouse model

CC Hsieh, YC Lo, HH Wang, HY Shen, YY Chen… - Translational …, 2024 - nature.com
Tuberous sclerosis complex (TSC) is a genetic disease that causes benign tumors and
dysfunctions in many organs, including the brain. Aside from the brain malformations, many …

Potential Crosstalk between the PACAP/VIP Neuropeptide System and Endoplasmic Reticulum Stress—Relevance to Multiple Sclerosis Pathophysiology

M Withana, A Castorina - Cells, 2023 - mdpi.com
Multiple sclerosis (MS) is an immune-mediated disorder characterized by focal
demyelination and chronic inflammation of the central nervous system (CNS). Although the …

Microglial Neuroinflammation-Independent Reversal of Demyelination of Corpus Callosum by Arsenic in a Cuprizone-Induced Demyelinating Mouse Model

S Kushwaha, J Saji, R Verma, V Singh, JA Ansari… - Molecular …, 2024 - Springer
Demyelination is the loss of myelin in CNS, resulting in damaged myelin sheath. Oxidative
stress and neuroinflammation play a key role in inducing demyelinating diseases like MS; …