[HTML][HTML] Presynaptic adenosine receptor heteromers as key modulators of glutamatergic and dopaminergic neurotransmission in the striatum
Adenosine plays a very significant role in modulating striatal glutamatergic and
dopaminergic neurotransmission. In the present essay we first review the extensive …
dopaminergic neurotransmission. In the present essay we first review the extensive …
Functional and pharmacological role of the dopamine D4 receptor and its polymorphic variants
The functional and pharmacological significance of the dopamine D4 receptor (D4R) has
remained the least well understood of all the dopamine receptor subtypes. Even more …
remained the least well understood of all the dopamine receptor subtypes. Even more …
Sensory Aspects of Restless Legs Syndrome: clinical, neurophysiological and neuroimaging prospectives.
E Antelmi, MP Mogavero, G Lanza, SM Cartella… - Sleep Medicine …, 2024 - Elsevier
Summary Restless Legs Syndrome (RLS) is a complex sensorimotor disorder, classified
among the sleep-related movement disorders. Although sensory symptoms appear as key …
among the sleep-related movement disorders. Although sensory symptoms appear as key …
[HTML][HTML] Iron toxicity, ferroptosis and microbiota in Parkinson's disease: Implications for novel targets
FV Carvalho, HE Landis, B Getachew… - Advances in …, 2024 - ncbi.nlm.nih.gov
Parkinson's Disease (PD) is a progressive neurodegenerative disease characterized by loss
of dopaminergic neurons in substantia nigra pars compacta (SNpc). Iron (Fe)-dependent …
of dopaminergic neurons in substantia nigra pars compacta (SNpc). Iron (Fe)-dependent …
[HTML][HTML] Putative animal models of restless legs syndrome: A systematic review and evaluation of their face and construct validity
Restless legs syndrome (RLS) is a sensorimotor disorder that severely affects sleep. It is
characterized by an urge to move the legs, which is often accompanied by periodic limb …
characterized by an urge to move the legs, which is often accompanied by periodic limb …
Review of the role of the endogenous opioid and melanocortin systems in the restless legs syndrome
Restless legs syndrome (RLS) is responsive to opioid, dopaminergic, and iron-based
treatments. Receptor blocker studies in RLS patients suggest that the therapeutic efficacy of …
treatments. Receptor blocker studies in RLS patients suggest that the therapeutic efficacy of …
Association of low serum ferritin levels with augmentation in patients with restless legs syndrome: A systematic review and meta-analysis
YS Li, WC Yeh, CY Hsu - Sleep Medicine, 2023 - Elsevier
Background Augmentation of restless legs syndrome (RLS) is an iatrogenic side effect
induced by dopaminergic agents, and it is a major cause of therapeutic failure. Iron …
induced by dopaminergic agents, and it is a major cause of therapeutic failure. Iron …
Unveiling the pathophysiology of restless legs syndrome through transcriptome analysis
MP Mogavero, M Salemi, G Lanza, A Rinaldi… - IScience, 2024 - cell.com
The aim of this study was to analyze signaling pathways associated with differentially
expressed messenger RNAs in people with restless legs syndrome (RLS). Seventeen RLS …
expressed messenger RNAs in people with restless legs syndrome (RLS). Seventeen RLS …
Circadian rhythm in restless legs syndrome
M Tang, Q Sun, Y Zhang, H Li, D Wang, Y Wang… - Frontiers in …, 2023 - frontiersin.org
Restless legs syndrome (RLS) is a sensorimotor disorder with a obvious circadian rhythm,
as its symptoms often occur or worsen only in the evening or at night. The mechanisms …
as its symptoms often occur or worsen only in the evening or at night. The mechanisms …
Why cells need iron: a compendium of iron utilisation
MR Teh, AE Armitage, H Drakesmith - Trends in Endocrinology & …, 2024 - cell.com
Iron deficiency is globally prevalent, causing an array of developmental, haematological,
immunological, neurological, and cardiometabolic impairments, and is associated with …
immunological, neurological, and cardiometabolic impairments, and is associated with …