Systolic and diastolic myocardial dysfunction has been demonstrated to be associated with
an activation of the circulating and local renin–angiotensin–aldosterone system (RAAS), and …

Aerobic exercise training leads to cardiovascular changes that markedly increase aerobic
power and lead to improved endurance performance. The functionally most important …

Abstract Angiotensin converting enzyme-2 (ACE2) is a multifunctional transmembrane
protein recently recognised as the entry receptor of the virus causing COVID-19. In the renin …

Chronic heart failure (CHF) impairs critical structural and functional components of the O2
transport pathway resulting in exercise intolerance and, consequently, reduced quality of …

A large body of evidence exists indicating that autonomic imbalance is characteristic of heart
failure, with several parameters of autonomic function associated with adverse clinical …

Atherosclerosis, a complex cardiovascular disease, is a leading cause of mortality and
morbidity worldwide. Oxidative stress and inflammation are both involved in the …

Although low levels of reactive oxygen species (ROS) are beneficial for the organism
ensuring normal cell and vascular function, the overproduction of ROS and increased …

Nakagawa and Sigmund Regulation of the Brain RAS 11 processing proteases including
tonin and cathepsin G with a broad spectrum of substrate affinities. 27 Ang-(1–12), a peptide …

Exercise training reduces renin-angiotensin system (RAS) activation, decreases plasma and
tissue oxidative stress and inflammation in hypertension. However, the temporal nature of …

• The renin-angiotensin system plays a key role in the control of blood pressure and fluid
homeostasis.• Growing evidence also reveals that hyperactivity of the renin-angiotensin …