Metabolic engineering advances and prospects for amino acid production

VF Wendisch - Metabolic engineering, 2020 - Elsevier
Amino acid fermentation is one of the major pillars of industrial biotechnology. The multi-
billion USD amino acid market is rising steadily and is diversifying. Metabolic engineering is …

The flexible feedstock concept in industrial biotechnology: metabolic engineering of Escherichia coli, Corynebacterium glutamicum, Pseudomonas, Bacillus and yeast …

VF Wendisch, LF Brito, MG Lopez, G Hennig… - Journal of …, 2016 - Elsevier
Most biotechnological processes are based on glucose that is either present in molasses or
generated from starch by enzymatic hydrolysis. At the very high, million-ton scale production …

[HTML][HTML] Comparative genomic analysis of the human gut microbiome reveals a broad distribution of metabolic pathways for the degradation of host-synthetized mucin …

DA Ravcheev, I Thiele - Frontiers in genetics, 2017 - frontiersin.org
The colonic mucus layer is a dynamic and complex structure formed by secreted and
transmembrane mucins, which are high-molecular-weight and heavily glycosylated proteins …

How bacteria utilize sialic acid during interactions with the host: snip, snatch, dispatch, match and attach

MP Jennings, CJ Day, JM Atack - Microbiology, 2022 - microbiologyresearch.org
N-glycolylneuraminic acid (Neu5Gc), and its precursor N-acetylneuraminic acid (Neu5Ac),
commonly referred to as sialic acids, are two of the most common glycans found in …

Improved fermentative production of gamma‐aminobutyric acid via the putrescine route: Systems metabolic engineering for production from glucose, amino sugars …

JMP Jorge, AQD Nguyen… - Biotechnology and …, 2017 - Wiley Online Library
Gamma‐aminobutyric acid (GABA) is a non‐protein amino acid widespread in Nature.
Among the various uses of GABA, its lactam form 2‐pyrrolidone can be chemically converted …

[HTML][HTML] Metabolic engineering for valorization of agri-and aqua-culture sidestreams for production of nitrogenous compounds by Corynebacterium glutamicum

VF Wendisch, KM Nampoothiri, JH Lee - Frontiers in Microbiology, 2022 - frontiersin.org
Corynebacterium glutamicum is used for the million-ton-scale production of amino acids.
Valorization of sidestreams from agri-and aqua-culture has focused on the production of …

Multiple evolutionary origins reflect the importance of sialic acid transporters in the colonization potential of bacterial pathogens and commensals

E Severi, M Rudden, A Bell, T Palmer… - Microbial …, 2021 - microbiologyresearch.org
Located at the tip of cell surface glycoconjugates, sialic acids are at the forefront of host–
microbe interactions and, being easily liberated by sialidase enzymes, are used as …

Independent component analysis of Corynebacterium glutamicum transcriptomes reveals its transcriptional regulatory network

J Zhao, X Sun, Z Mao, Y Zheng, Z Geng, Y Zhang… - Microbiological …, 2023 - Elsevier
Gene expression in bacteria is regulated by multiple transcription factors. Clarifying the
regulation mechanism of gene expression is necessary to understand bacterial …

Transcriptional responses of Streptococcus gordonii and Fusobacterium nucleatum to coaggregation

NVR Mutha, WK Mohammed… - Molecular oral …, 2018 - Wiley Online Library
Cell‐cell interactions between genetically distinct bacteria, known as coaggregation, are
important for the formation of mixed‐species biofilms such as dental plaque. Interactions …

Pyrimirhodomyrtone inhibits Staphylococcus aureus by affecting the activity of NagA

H Zeng, M Cheng, J Liu, C Hu, S Lin, R Cui, H Li… - Biochemical …, 2023 - Elsevier
The epidemic of methicillin-resistant Staphylococcus aureus (MRSA) infections has created
a critical health threat. The drug resistance of MRSA makes the development of drugs with …