Vagal afferent innervation of the airways in health and disease
SB Mazzone, BJ Undem - Physiological reviews, 2016 - journals.physiology.org
Vagal sensory neurons constitute the major afferent supply to the airways and lungs.
Subsets of afferents are defined by their embryological origin, molecular profile …
Subsets of afferents are defined by their embryological origin, molecular profile …
Adverse effects of cigarette and noncigarette smoke exposure on the autonomic nervous system: mechanisms and implications for cardiovascular risk
HR Middlekauff, J Park, RS Moheimani - Journal of the American College of …, 2014 - jacc.org
This review summarizes the detrimental effects of cigarette and noncigarette emission
exposure on autonomic function, with particular emphasis on the mechanisms of acute and …
exposure on autonomic function, with particular emphasis on the mechanisms of acute and …
Silencing nociceptor neurons reduces allergic airway inflammation
S Talbot, REE Abdulnour, PR Burkett, S Lee… - Neuron, 2015 - cell.com
Lung nociceptors initiate cough and bronchoconstriction. To elucidate if these fibers also
contribute to allergic airway inflammation, we stimulated lung nociceptors with capsaicin and …
contribute to allergic airway inflammation, we stimulated lung nociceptors with capsaicin and …
Neuroimmunity: physiology and pathology
Evolution has yielded multiple complex and complementary mechanisms to detect
environmental danger and protect tissues from damage. The nervous system rapidly …
environmental danger and protect tissues from damage. The nervous system rapidly …
Airway smooth muscle in airway reactivity and remodeling: what have we learned?
YS Prakash - American Journal of Physiology-Lung Cellular …, 2013 - journals.physiology.org
It is now established that airway smooth muscle (ASM) has roles in determining airway
structure and function, well beyond that as the major contractile element. Indeed, changes in …
structure and function, well beyond that as the major contractile element. Indeed, changes in …
A review on the role of TRP channels and their potential as drug targets_an insight into the TRP channel drug discovery methodologies
HP Fallah, E Ahuja, H Lin, J Qi, Q He, S Gao… - Frontiers in …, 2022 - frontiersin.org
Transient receptor potential (TRP) proteins are a large group of ion channels that control
many physiological functions in our body. These channels are considered potential …
many physiological functions in our body. These channels are considered potential …
[HTML][HTML] Capsaicin-evoked cough responses in asthmatic patients: evidence for airway neuronal dysfunction
I Satia, N Tsamandouras, K Holt, H Badri… - Journal of Allergy and …, 2017 - Elsevier
Background Cough in asthmatic patients is a common and troublesome symptom. It is
generally assumed coughing occurs as a consequence of bronchial hyperresponsiveness …
generally assumed coughing occurs as a consequence of bronchial hyperresponsiveness …
Transcriptional profiling of individual airway projecting vagal sensory neurons
Bronchopulmonary sensory neurons are derived from the vagal sensory ganglia and are
essential for monitoring the physical and chemical environment of the airways and lungs …
essential for monitoring the physical and chemical environment of the airways and lungs …
Inhibition of leptin regulation of parasympathetic signaling as a cause of extreme body weight-associated asthma
Impaired lung function caused by decreased airway diameter (bronchoconstriction) is
frequently observed whether body weight is abnormally high or low. That these opposite …
frequently observed whether body weight is abnormally high or low. That these opposite …
Sense and immunity: context-dependent neuro-immune interplay
The sensory nervous and immune systems, historically considered autonomous, actually
work in concert to promote host defense and tissue homeostasis. These systems interact …
work in concert to promote host defense and tissue homeostasis. These systems interact …