Glycine transporters are endogenous regulators of the dual functions of glycine, which acts
as a classical inhibitory neurotransmitter at glycinergic synapses and as a modulator of …

Pharmacotherapy of schizophrenia based on the dopamine hypothesis remains
unsatisfactory for the negative and cognitive symptoms of the disease. Enhancing N-methyl …

The term “fat” may refer to lipids as well as the cells and tissue that store lipid (ie, adipocytes
and adipose tissue).“Lipid” is derived from “lipos,” which refers to animal fat or vegetable oil …

Translational control depends on phosphorylation of eIF2α by PKR-like ER kinase (PERK).
To examine the role of PERK in cognitive function, we selectively disrupted PERK …

An endophenotype is a heritable trait that is generally considered to be more highly,
associated with a gene-based neurological deficit than a disease phenotype itself. Such …

Dopamine D2 receptor blockade has been an obligate mechanism of action present in all
medications that effectively treat positive symptoms of schizophrenia (eg, delusions and …

Hypofunction of the N-methyl-d-aspartate receptor (NMDAR) has been implicated in the
pathophysiology of schizophrenia. The NMDAR contains a d-serine/glycine site on the NR1 …

Summary The glycine transporter 1 (GlyT1) plays a crucial role in the regulation of both
inhibitory and excitatory neurotransmission by removing glycine from the synaptic cleft …

The glutamate neurotransmitter system is one of the major candidate pathways for the
pathophysiology of schizophrenia, and increased understanding of the pharmacology …

Latent inhibition (LI) is a cross species selective attention phenomenon reflecting a
modulating effect of past experience with inconsequential stimuli on current task …