Abstract Alzheimer's Disease (AD), the most prevalent neurodegenerative disease of aging,
affects one in eight older Americans. Nearly all drug treatments tested for AD today have …

Obesity mediates most of its direct medical sequelae through the development of insulin
resistance (IR). The cellular effects of insulin occur through two main postreceptor pathways …

There is growing evidence that patients with Type 2 diabetes have an increased risk of
developing Parkinson's disease and share similar dysregulated pathways suggesting …

Peroxisome proliferator-activated receptor (PPAR) β/δ belongs to the family of hormone and
lipid-activated nuclear receptors, which are involved in metabolism of long-chain fatty acids …

MicroRNAs (miRNAs) are small non-coding RNA which have been shown to regulate gene
expression. The alteration ofmiRNAs expression has been associated with several …

The complexity of Alzheimer's disease (AD) complicates the search for effective treatments.
While the key roles of pathologically modified proteins has occupied a central role in …

This study aimed to prepare and characterize chitosan-Transfersulin (CTI) as an effective
intranasal drug delivery system (IDDS) for the treatment of memory disorders by mediating …

Global obesity is a pandemic status, estimated to affect over 2 billion people, that has
resulted in an enormous strain on healthcare systems worldwide. The situation is …

The brain exchanges nutrients and small molecules with blood via the blood–brain barrier
(BBB). Approximately 20% energy intake for the body is consumed by the brain. Glucose is …

With the constant failure of the clinical trials continuous exploration of a therapeutic target
against Alzheimer's disease (AD) is the utmost need. Numerous studies have supported the …