Drug addiction represents a dramatic dysregulation of motivational circuits that is caused by
a combination of exaggerated incentive salience and habit formation, reward deficits and …

A decade ago, we hypothesized that drug addiction can be viewed as a transition from
voluntary, recreational drug use to compulsive drug-seeking habits, neurally underpinned by …

There is increasing interest among functional neurosurgeons in the potential for novel
therapies to impact upon diseases beyond movement disorders and pain. A target of …

I propose a reconceptualization of key phenomena important in the study of emotion—those
phenomena that reflect functions and circuits related to survival, and that are shared by …

The word 'addiction'these days is used to refer to a chronic condition where there is an
unhealthily powerful motivation to engage in a particular behaviour. This can be driven by …

Both drug addiction and obesity can be defined as disorders in which the saliency value of
one type of reward (drugs and food, respectively) becomes abnormally enhanced relative to …

BACKGROUND: The biological mechanisms that link the development of depression to
metabolic disorders such as obesity and diabetes remain obscure. Dopamine-and plasticity …

We hypothesize that drug addiction can be viewed as the endpoint of a series of transitions
from initial voluntary drug use through the loss of control over this behaviour, such that it …

This review discusses conceptual issues in relating temperament to psychopathology,
including the disputed relation of temperament to personality in children. A potential …

The addictions are common chronic psychiatric diseases that today are prevented and
treated using relatively untargeted and only partially effective methods. The addictions are …