Microglia are key to maintaining the homeostasis of the brain. These immune cells of the
brain can be our biggest ally in fighting infections, but can worsen pathology or hinder …

The endocannabinoid system (ECS) is ubiquitous in most human tissues, and involved in
the regulation of mental health. Consequently, its dysregulation is associated with …

G protein-gated inwardly rectifying potassium channels (Kir3/GirK) are important for
maintaining resting membrane potential, cell excitability and inhibitory neurotransmission …

Despite low levels of cannabinoid receptor type 2 (CB2R) expression in the central nervous
system in human and rodents, a growing body of evidence shows CB2R involvement in …

The endocannabinoid system (ECS) is composed of the two canonical receptor subtypes;
type-1 cannabinoid (CB1R) and type 2 receptor (CB2R), endocannabinoids (eCBs) and …

Different data suggest that microglia may participate in the drug addiction process as these
cells respond to neurochemical changes induced by the administration of these substances …

Cocaine abuse continues to be a serious health problem worldwide. Despite intense
research, there is still no FDA-approved medication to treat cocaine use disorder (CUD). In …

Kratom is a widely abused plant-based drug preparation with a global interest in recent
years, well beyond its native grounds in Southeast Asia. Mitragynine, its major psychoactive …

Schizophrenia is a complex disorder that involves several neurotransmitters such as
dopamine, glutamate, and GABA. More recently, the endocannabinoid system has also …

The aim of this study was to evaluate the effects of cannabidiol (CBD) on the behavioural
and gene expression changes in a new animal model of spontaneous cocaine withdrawal …