Summary Hypoxia-inducible factor (HIF), a central regulator for detecting and adapting to
cellular oxygen levels, transcriptionally activates genes modulating oxygen homeostasis …

Introduction: Hypoxia is one of the intrinsic features of solid tumors, and it is always
associated with aggressive phenotypes, including resistance to radiation and …

Oxygen deprivation or hypoxia characterizes a number of serious pathological conditions
and elicits a number of adaptive changes that are mainly mediated at the transcriptional …

Acute kidney injury (AKI) is a major kidney disease characterized by an abrupt loss of renal
function. Accumulating evidence indicates that incomplete or maladaptive repair after AKI …

The cellular response to oxygen deprivation is governed largely by a family of transcription
factors known as Hypoxia Inducible Factors (HIFs). This review focuses on the molecular …

Hypoxia-inducible factors (HIFs) are broadly expressed in human cancers, and HIF1α and
HIF2α were previously suspected to promote tumour progression through largely …

The hypoxia-inducible factors (HIFs) coordinate cellular adaptations to low oxygen stress by
regulating transcriptional programs in erythropoiesis, angiogenesis and metabolism. These …

Hypoxia‐inducible factor 1 (HIF‐1) is a transcriptional activator of various genes related to
cellular adaptive responses to hypoxia. Dysfunctions in the regulatory systems of HIF‐1 …

The hypoxia signalling pathway enables adaptation of cells to decreased oxygen
availability. When oxygen becomes limiting, the central transcription factors of the pathway …

Members of the highly conserved and ubiquitously expressed pleiotropic CK1 family play
major regulatory roles in many cellular processes including DNA-processing and repair …