Recent research progress has given detailed knowledge on the molecular pathogenesis of
Alzheimer's disease (AD), which has been translated into an intense, ongoing development …

Multiple Sclerosis (MS) is an inflammatory disease of the Central Nervous System with
multifocal areas of demyelination. Although its etiology and pathogenesis remain …

A great variety of neurological diseases require investigation of cerebrospinal fluid (CSF) to
prove the diagnosis or to rule out relevant differential diagnoses. The objectives were to …

Tumor necrosis factor-α (TNF-α) has well recognized effects on cerebral endothelial cells
and, therefore, may mediate disruption of blood-brain barrier in patients with multiple …

Introduction Multiple sclerosis (MS) is the most frequent demyelinating disease of the central
nervous system. Although there is currently there is no definite cure for MS, new therapies …

Objective To determine the best method to measure intrathecal immunoglobulin (Ig) M
synthesis (ITMS), a biomarker of worse prognosis in multiple sclerosis (MS). We compared …

Background: Cerebrospinal fluid (CSF) kappa free light chains (KFLC) are gaining
increasing interest as markers of intrathecal immunoglobulin synthesis. The main aim of this …

For many years, quantifiable biomarkers in neurological diseases have represented a hot
topic. In multiple sclerosis (MS), cerebrospinal fluid biomarkers have played a diagnostic …

The identity of target antigen (s) in multiple sclerosis (MS) remains elusive despite much
effort to identify it. We analyzed cerebrospinal fluid (CSF) from patients with MS, other …

Background The ability to predict the future progression of MS represents a key issue for the
neurologist. The aim of the study was to create a multifactorial prognostic index (MPI) …