As a drug of abuse tightens its hold on addicted individuals, aspects of life that once brought
pleasure lose their appeal while attention and motivation are turned toward acquiring drug …

To re-examine the paradoxical effect hypothesis of abused drugs, the present study
concerned whether different doses of morphine disparately affect neuronal activity and …

Rationale Trace amine-associated receptor 1 (TAAR1) is the best-studied receptor of trace
amines, a group of biogenic amines expressed at a relatively low level in the mammalian …

Recently, use of the synthetic cathinone (aka “bath salt”) eutylone has risen in the United
States and globally. Due to its novelty in drug markets, its affective properties remain largely …

Background Drugs of abuse have rewarding and aversive effects that, in balance, impact
abuse potential. Although such effects are generally examined in independent assays (eg …

Background: Prior work has reported that a drug's aversive effects (as indexed by taste
avoidance conditioning) are attenuated when the pre-exposure and conditioning drugs are …

Methods 56 healthy men and women with prior exposure to cannabis but no history of CUD
participated in a randomized, placebo-controlled, human laboratory study where they …

The impacts of high-fat and/or high-sugar diets on opioid-induced effects are well
documented; however, little is known about the effect of such diet on the affective responses …

Highlights Eutylone induced dose-dependent CTA and CPP. MDMA pre-exposure
attenuated eutylone-induced CTA, but it did not impact eutylone-induced CPP. Cocaine pre …

The use of both prescription and illicit drugs creates the potential for drug interactions as a
function of both pharmacokinetic and pharmacodynamic processes. One such interaction is …