Body composition exhibits marked variations across the early human lifetime. The precise
physiological mechanisms that drive such developmental adaptations are difficult to …

Testosterone is a pleiotropic hormone that plays an important role in the human body.
Classically, testosterone was thought to be predominantly involved in androgenesis and …

Background: Commercially available testosterone immunoassays give divergent results,
especially at the low concentrations seen in women. We compared immunoassays and a …

Context Transgender adolescents can receive gonadotropin-releasing hormone analogues
(GnRH) and gender-affirming hormone therapy (GAHT), but little is known about effects on …

Puberty is the stage of growth leading to sexual maturity and reproductive capacity. In girls,
the initial physical changes are breast development; in boys, testicular growth—both …

Central precocious puberty (CPP) is characterized by early pubertal changes, acceleration
of growth velocity, and rapid bone maturation that often result in reduced adult height. An …

Celebrating more than twenty years as the single best source in the field, this Fifth Edition
has now expanded into two cornerstone volumes with 53 fully inclusive chapters and 73 …

Purpose To investigate the effectiveness and safety of gonadotropin-releasing hormone
analogue (GnRHa) in combination with recombinant human growth hormone (rhGH) in girls …

Objective. A 3‐month depot of leuprorelin acetate (LA) was introduced in China in July 2020.
However, the clinical experience is limited. The purpose of this study was to compare the …

Sex steroids are critical for skeletal development and maturation during puberty as well as
for skeletal maintenance during adult life. However, the exact time during puberty when sex …