Deep brain stimulation for Alzheimer's disease: stimulation parameters and potential mechanisms of action

Y Luo, Y Sun, X Tian, X Zheng, X Wang, W Li… - Frontiers in aging …, 2021 - frontiersin.org
Deep brain stimulation (DBS) is a neurosurgical technique that regulates neuron activity by
using internal pulse generators to electrodes in specific target areas of the brain. As a blind …

Deep brain stimulation beyond the clinic: Navigating the future of Parkinson's and Alzheimer's disease therapy

DKL Senevirathne, A Mahboob, K Zhai, P Paul… - Cells, 2023 - mdpi.com
Deep brain stimulation (DBS) is a surgical procedure that uses electrical neuromodulation to
target specific regions of the brain, showing potential in the treatment of neurodegenerative …

Neuroprotection and non-invasive brain stimulation: Facts or fiction?

M Guidetti, A Bertini, F Pirone, G Sala… - International Journal of …, 2022 - mdpi.com
Non-Invasive Brain Stimulation (NIBS) techniques, such as transcranial Direct Current
Stimulation (tDCS) and repetitive Magnetic Transcranial Stimulation (rTMS), are well-known …

Alzheimer's disease: An evolving understanding of noradrenergic involvement and the promising future of electroceutical therapies

C Slater, Q Wang - Clinical and Translational Medicine, 2021 - Wiley Online Library
Alzheimer's disease (AD) poses a significant global health concern over the next several
decades. Multiple hypotheses have been put forth that attempt to explain the underlying …

Deep brain stimulation of the nucleus basalis of Meynert modulates hippocampal–frontoparietal networks in patients with advanced Alzheimer's disease

Y Jiang, TS Yuan, YC Chen, P Guo, TH Lian… - Translational …, 2022 - Springer
Background Deep brain stimulation (DBS) of the nucleus basalis of Meynert (NBM) has
shown potential for the treatment of mild-to-moderate Alzheimer's disease (AD). However …

Deep brain stimulation for alzheimer's disease: tackling circuit dysfunction

J Lam, J Lee, CY Liu, AM Lozano, DJ Lee - … : Technology at the Neural …, 2021 - Elsevier
Abstract Objectives Treatments for Alzheimer's disease are urgently needed given its
enormous human and economic costs and disappointing results of clinical trials targeting …

Synthesis and AChE-inhibitory activity of new benzimidazole derivatives

U Acar Cevik, BN Saglik, S Levent, D Osmaniye… - Molecules, 2019 - mdpi.com
Alzheimer's disease (AD), one of the main causes of aged dementia, is a progressive and
degenerative neurological disorder characterized by loss of cognition and memory …

Deep brain stimulation for the treatment of Alzheimer's disease: A systematic review and meta-analysis

A Majdi, Z Deng, S Sadigh-Eteghad… - Frontiers in …, 2023 - frontiersin.org
Background One of the experimental neuromodulation techniques being researched for the
treatment of Alzheimer's disease (AD) is deep brain stimulation (DBS). To evaluate the …

Neuromodulation and the Gut–Brain Axis: Therapeutic Mechanisms and Implications for Gastrointestinal and Neurological Disorders

B Aljeradat, D Kumar, S Abdulmuizz, M Kundu… - Pathophysiology, 2024 - mdpi.com
The gut–brain axis (GBA) represents a complex, bidirectional communication network that
intricately connects the gastrointestinal tract with the central nervous system (CNS) …

Deep brain stimulation in Alzheimer's disease: Targeting the nucleus basalis of Meynert

Y Chen, K Shu, H Kang - Journal of Alzheimer's Disease, 2021 - content.iospress.com
Alzheimer's disease (AD) is becoming a prevalent disease in the elderly population. Past
decades have witnessed the development of drug therapies with varying targets. However …