Cardiac energy metabolism in heart failure
Alterations in cardiac energy metabolism contribute to the severity of heart failure. However,
the energy metabolic changes that occur in heart failure are complex and are dependent not …
the energy metabolic changes that occur in heart failure are complex and are dependent not …
Mitochondrial quality control in health and in Parkinson's disease
As a central hub for cellular metabolism and intracellular signaling, the mitochondrion is a
pivotal organelle, dysfunction of which has been linked to several human diseases including …
pivotal organelle, dysfunction of which has been linked to several human diseases including …
PGC-1α is a master regulator of mitochondrial lifecycle and ROS stress response
Mitochondria play a major role in ROS production and defense during their life cycle. The
transcriptional activator PGC-1α is a key player in the homeostasis of energy metabolism …
transcriptional activator PGC-1α is a key player in the homeostasis of energy metabolism …
CPT1A-mediated fat oxidation, mechanisms, and therapeutic potential
IR Schlaepfer, M Joshi - Endocrinology, 2020 - academic.oup.com
Energy homeostasis during fasting or prolonged exercise depends on mitochondrial fatty
acid oxidation (FAO). This pathway is crucial in many tissues with high energy demand and …
acid oxidation (FAO). This pathway is crucial in many tissues with high energy demand and …
PINK1 and Parkin mitochondrial quality control: a source of regional vulnerability in Parkinson's disease
That certain cell types in the central nervous system are more likely to undergo
neurodegeneration in Parkinson's disease is a widely appreciated but poorly understood …
neurodegeneration in Parkinson's disease is a widely appreciated but poorly understood …
[HTML][HTML] Expansion of T memory stem cells with superior anti-tumor immunity by Urolithin A-induced mitophagy
D Denk, V Petrocelli, C Conche, M Drachsler… - Immunity, 2022 - cell.com
T memory stem cells (T SCM) display increased self-renewal and prolonged survival
capabilities, thus preventing T cell exhaustion and promoting effective anti-tumor T cell …
capabilities, thus preventing T cell exhaustion and promoting effective anti-tumor T cell …
Mitochondrial energetics in the kidney
P Bhargava, RG Schnellmann - Nature Reviews Nephrology, 2017 - nature.com
The kidney requires a large number of mitochondria to remove waste from the blood and
regulate fluid and electrolyte balance. Mitochondria provide the energy to drive these …
regulate fluid and electrolyte balance. Mitochondria provide the energy to drive these …
Organism-wide, cell-type-specific secretome mapping of exercise training in mice
There is a significant interest in identifying blood-borne factors that mediate tissue crosstalk
and function as molecular effectors of physical activity. Although past studies have focused …
and function as molecular effectors of physical activity. Although past studies have focused …
Nrf2 as a regulator of mitochondrial function: Energy metabolism and beyond
N Esteras, AY Abramov - Free Radical Biology and Medicine, 2022 - Elsevier
Mitochondria are unique and essential organelles that mediate many vital cellular processes
including energy metabolism and cell death. The transcription factor Nrf2 (NF-E2 p45 …
including energy metabolism and cell death. The transcription factor Nrf2 (NF-E2 p45 …
[HTML][HTML] Diverse roles of mitochondria in ischemic stroke
Stroke is the leading cause of adult disability and mortality in most developing and
developed countries. The current best practices for patients with acute ischemic stroke …
developed countries. The current best practices for patients with acute ischemic stroke …