Abstract Sirtuin 3 (SIRT3) is one of the most prominent deacetylases that can regulate
acetylation levels in mitochondria, which are essential for eukaryotic life and inextricably …

The NAD+-dependent protein lysine deacylases of the Sirtuin family regulate various
physiological functions, from energy metabolism to stress responses. The human Sirtuin …

Diabetic kidney disease is known as a major cause of chronic kidney disease and end stage
renal disease. Polysulfides, a class of chemical agents with a chain of sulfur atoms, are …

Post-translational acetylation of lysine residues has emerged as a key regulatory
mechanism in all eukaryotic organisms. Originally discovered in 1963 as a unique …

Sirtuins are NAD+-dependent histone deacetylases regulating important metabolic
pathways in prokaryotes and eukaryotes and are involved in many biological processes …

Sirtuins are NAD+ dependent histone deacetylases (HDAC) that play a pivotal role in
neuroprotection and cellular senescence. SIRT1-7 are different homologs from sirtuins. They …

Recent studies in mice have identified single molecules that can delay multiple diseases of
aging and extend lifespan. In theory, such molecules could prevent dozens of diseases …

Mitochondrial fission-fusion dynamics and mitochondrial bioenergetics, including oxidative
phosphorylation and generation of ATP, are strongly clock controlled. Here we show that …

Bioenergetic preferences of cancer cells foster tumor acidosis that in turn leads to dramatic
reduction in glycolysis and glucose-derived acetyl-coenzyme A (acetyl-CoA). Here, we show …

For a little over a decade now, the Macromolecular Crystallography (MX) group at the
Helmholtz-Zentrum Berlin (HZB) has been operating three state-of-the-art synchrotron …