Physical activity and sports play major roles in the overall health status of humans. It is well
known that regular exercise helps to lower the risk for a broad variety of health problems …

Abstract Cardiovascular (CV) disease (CVD) remains the leading cause of major morbidity
and CVD-and all-cause mortality in most of the world. It is now clear that regular physical …

Exercise training is continually challenging whole-body homeostasis, leading to
improvements in performance and health. Adaptations to exercise training are complex and …

Circulating cell-free microRNAs (miRNAs) represent a major reservoir for biomarker
discovery. Unfortunately, their implementation in clinical practice is limited due to a profound …

Physical exercise represents one of the strongest physiological stimuli capable to induce
functional and structural modifications in all biological systems. Indeed, beside the …

Circulating microRNAs (miRNAs, miRs) have great potential as cardiac biomarkers and they
are also being explored for their roles in intercellular communication and gene expression …

Regular physical exercise has been recognized as a potent modulator of immune function,
with its effects including enhanced immune surveillance, reduced inflammation, and …

Background Interorgan communication networks established during exercise in several
different tissues can be mediated by several exercise-induced factors. Therefore, the present …

Abstract Background Skeletal muscle (SkM) is a large, secretory organ that produces and
releases myokines that can have autocrine, paracrine, and endocrine effects. Whether …

Endothelial function typically exhibits a hormetic response to exercise. It is unknown whether
endothelial damage occurs in response to acute exercise and could be a contributing …