IgA nephropathy

E Stamellou, C Seikrit, SCW Tang, P Boor… - Nature Reviews …, 2023 - nature.com
IgA nephropathy (IgAN), the most prevalent primary glomerulonephritis worldwide, carries a
considerable lifetime risk of kidney failure. Clinical manifestations of IgAN vary from …

[HTML][HTML] Pathogenesis of IgA vasculitis: an up-to-date review

Y Song, X Huang, G Yu, J Qiao, J Cheng, J Wu… - Frontiers in …, 2021 - frontiersin.org
Immunoglobin A (IgA) vasculitis (IgAV), formerly called the Henoch-Schönlein purpura
(HSP), is a small vessel vasculitis, characterized by IgA1-dominant immune deposition at …

[HTML][HTML] Role of the Innate Immune Response in Glomerular Disease Pathogenesis: Focus on Podocytes

W Issa, R Njeim, A Carrazco, GW Burke, A Mitrofanova - Cells, 2024 - mdpi.com
Accumulating evidence indicates that inflammatory and immunologic processes play a
significant role in the development and progression of glomerular diseases. Podocytes, the …

Immune abnormalities in IgA nephropathy

M Gentile, L Sanchez-Russo, LV Riella… - Clinical Kidney …, 2023 - academic.oup.com
ABSTRACT Immunoglobulin A (IgA) nephropathy (IgAN) is the most common primary
glomerulonephritis worldwide and it is characterized by mesangial IgA deposition …

Emerging role of monoclonal antibodies in the treatment of IgA nephropathy

D Maixnerova, V Tesar - Expert Opinion on Biological Therapy, 2023 - Taylor & Francis
Introduction IgA nephropathy is the most common primary glomerulonephritis worldwide.
Immune complexes, composed of galactose-deficient IgA1 and Gd-IgA1 autoantibodies, are …

New treatment strategies for IgA nephropathy: targeting plasma cells as the main source of pathogenic antibodies

D Maixnerova, D El Mehdi, DV Rizk, H Zhang… - Journal of Clinical …, 2022 - mdpi.com
Immunoglobulin A nephropathy (IgAN) is a rare autoimmune disorder and the leading cause
of biopsy-reported glomerulonephritis (GN) worldwide. Disease progression is driven by the …

Biological role, mechanism of action and the importance of interleukins in kidney diseases

P Mertowska, S Mertowski, I Smarz-Widelska… - International journal of …, 2022 - mdpi.com
Each year, the number of patients who are diagnosed with kidney disease too late is
increasing, which leads to permanent renal failure. This growing problem affects people of …

TGF-β1 signaling: immune dynamics of chronic kidney diseases

PCT Tang, ASW Chan, CB Zhang… - Frontiers in …, 2021 - frontiersin.org
Chronic kidney disease (CKD) is a major cause of morbidity and mortality worldwide,
imposing a great burden on the healthcare system. Regrettably, effective CKD therapeutic …

Zhen-Wu-Tang protects IgA nephropathy in rats by regulating exosomes to inhibit NF-κB/NLRP3 pathway

H Li, R Lu, Y Pang, J Li, Y Cao, H Fu, G Fang… - Frontiers in …, 2020 - frontiersin.org
Immunoglobulin A nephropathy (IgAN) is one of the most frequent kinds of primary
glomerulonephritis characterized by IgA immune complexes deposition and glomerular …

Gut-kidney axis in IgA nephropathy: Role on mesangial cell metabolism and inflammation

MJ Luvizotto, L Menezes-Silva, V Woronik… - Frontiers in Cell and …, 2022 - frontiersin.org
IgA Nephropathy (IgAN) is the commonest primary glomerular disease around the world and
represents a significant cause of end-stage renal disease. IgAN is characterized by …