[HTML][HTML] Mechanisms of taxane resistance
SM Maloney, CA Hoover, LV Morejon-Lasso… - Cancers, 2020 - mdpi.com
Simple Summary Drug resistance is prevalent in many types of cancer and decreases
patient survival. The taxanes are anti-mitotic chemotherapeutic agents, widely used since …
patient survival. The taxanes are anti-mitotic chemotherapeutic agents, widely used since …
The interactions of docetaxel with tumor microenvironment
R Gupta, MM Kadhim, AT Jalil, MQ Alasheqi… - International …, 2023 - Elsevier
There are several interactions within the tumor microenvironment (TME) that affect the
response of cancer cells to therapy. There are also a large number of cells and secretions in …
response of cancer cells to therapy. There are also a large number of cells and secretions in …
[HTML][HTML] βIII-tubulin gene regulation in health and disease
AMP Duly, FCL Kao, WS Teo… - Frontiers in Cell and …, 2022 - frontiersin.org
Microtubule proteins form a dynamic component of the cytoskeleton, and play key roles in
cellular processes, such as vesicular transport, cell motility and mitosis. Expression of …
cellular processes, such as vesicular transport, cell motility and mitosis. Expression of …
[HTML][HTML] Effects of hypoxia on human cancer cell line chemosensitivity
S Strese, M Fryknäs, R Larsson, J Gullbo - BMC cancer, 2013 - Springer
Background Environment inside even a small tumor is characterized by total (anoxia) or
partial oxygen deprivation,(hypoxia). It has been shown that radiotherapy and some …
partial oxygen deprivation,(hypoxia). It has been shown that radiotherapy and some …
Hypoxia, notch signalling, and prostate cancer
L Marignol, K Rivera-Figueroa, T Lynch… - Nature Reviews …, 2013 - nature.com
The notch signalling pathway is involved in differentiation, proliferation, angiogenesis,
vascular remodelling, and apoptosis. Deregulated expression of notch receptors, ligands …
vascular remodelling, and apoptosis. Deregulated expression of notch receptors, ligands …
βIII-Tubulin: biomarker of taxane resistance or drug target?
Introduction: βIII-Tubulin (TUBB3) is predominantly expressed in neurons of the central and
peripheral nervous systems, while in normal non-neoplastic tissues it is barely detectable …
peripheral nervous systems, while in normal non-neoplastic tissues it is barely detectable …
[HTML][HTML] Hsa-miR-210-3p expression in breast cancer and its putative association with worse outcome in patients treated with Docetaxel
B Pasculli, R Barbano, M Rendina, A Fontana… - Scientific reports, 2019 - nature.com
Abstract MicroRNA-210-3p is the most prominent hypoxia regulated microRNA, and it has
been found significantly overexpressed in different human cancers. We performed the …
been found significantly overexpressed in different human cancers. We performed the …
Hypoxia and noncoding RNAs in taxane resistance
P Pucci, P Rescigno, S Sumanasuriya… - Trends in …, 2018 - cell.com
Taxanes are chemotherapeutic drugs employed in the clinic to treat a variety of
malignancies. Despite their overall efficacy, cancer cells often display resistance to taxanes …
malignancies. Despite their overall efficacy, cancer cells often display resistance to taxanes …
[HTML][HTML] Emerging targets to monitor and overcome docetaxel resistance in castration resistant prostate cancer
L Magadoux, N Isambert… - International …, 2014 - spandidos-publications.com
Drug development for castration resistant prostate cancer (CRPC) is challenging, since this
cancer is still associated with high mortality and limited therapeutic options. In 2004 …
cancer is still associated with high mortality and limited therapeutic options. In 2004 …
TUBB3 is associated with high-grade histology, poor prognosis, p53 expression, and cancer stem cell markers in clear cell renal cell carcinoma
Y Sekino, X Han, T Babasaki, S Miyamoto, H Kitano… - Oncology, 2020 - karger.com
Background: βIII-Tubulin, encoded by the TUBB3 gene, is a microtubule protein. Several
studies have shown that overexpression of TUBB3 is linked to poor prognosis and is …
studies have shown that overexpression of TUBB3 is linked to poor prognosis and is …