The role of ATP as an extracellular signalling molecule is now well established and
evidence is accumulating that ATP and other nucleotides (ADP, UTP and UDP) play …

There are nineteen different receptor proteins for adenosine, adenine and uridine
nucleotides, and nucleotide sugars, belonging to three families of G protein-coupled …

The past half century has witnessed tremendous advances in our understanding of
extracellular purinergic signaling pathways. Purinergic neurotransmission, in particular, has …

Left ventricular hypertrophy (LVH) can be adaptive, as arising from exercise, or pathological,
most commonly when driven by hypertension. The pathophysiology of LVH is consistently …

Recently, there has been much interest in gene–disease networks and polypharmacology
as a basis for drug repositioning. Here, we integrate data from structural and chemical …

This review considers the expression and roles of P2X receptors in the cardiovascular
system in health and disease and their potential as therapeutic targets. P2X receptors are …

The purine-and pyrimidine-sensitive P2Y receptors belong to the large group of G-protein-
coupled receptors that are the target of approximately one-third of the pharmaceutical drugs …

Sympathetic control of arteries and veins may be altered in hypertension. To test this
hypothesis, constrictions of mesenteric arteries and veins caused by nerve stimulation and …

K+ secretion by strial marginal cell and vestibular dark cell epithelia is regulated by UTP and
ATP at both the apical and basolateral membranes, suggesting control by P2Y2 and/or …

As arteries are resistance blood vessels while veins perform a capacitance function, it might
be expected that sympathetic neural control of arteries and veins would differ. The function …