The high selectivity and affinity of antibodies toward their antigens have made them a highly
valuable tool in disease therapy, diagnosis, and basic research. A plethora of chemical and …

Targeted protein degradation (TPD) has emerged in the past decade as a major new drug
modality to remove intracellular proteins with bispecific small molecules that recruit the …

Antibody development, delivery, and efficacy are influenced by antibody-antigen affinity
interactions, off-target interactions that reduce antibody bioavailability and …

Targeted eradication of transformed or otherwise dysregulated cells using monoclonal
antibodies (mAb), antibody–drug conjugates (ADC), T cell engagers (TCE), or chimeric …

Cancer immunotherapy is a method of controlling and eliminating tumors by reactivating the
body's cancer-immunity cycle and restoring its antitumor immune response. The increased …

Conventional directed evolution methods offer the ability to select bioreceptors with high
binding affinity for a specific target in terms of thermodynamic properties. However, there is a …

Herein, we describe the generation of potent NK cell engagers (NKCEs) based on single
domain antibodies (sdAbs) specific for NKp46 harboring the humanized Fab version of …

Adipokines play a significant role in cardiometabolic diseases. Asprosin, a newly discovered
adipokine, was first identified as a glucose-raising protein hormone. Asprosin also …

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are fatal
neurodegenerative disorders on a disease spectrum that are characterized by the …

Biologics, such as antibodies and enzymes, are crucial in research, biotechnology,
diagnostics, and therapeutics. Often, biologics with suitable functionality are discovered, but …