Pericyte control of blood flow across microvascular zones in the central nervous system
DA Hartmann, V Coelho-Santos… - Annual review of …, 2022 - annualreviews.org
The vast majority of the brain's vascular length is composed of capillaries, where our
understanding of blood flow control remains incomplete. This review synthesizes current …
understanding of blood flow control remains incomplete. This review synthesizes current …
Neurovascular coupling mechanisms in health and neurovascular uncoupling in Alzheimer's disease
To match the metabolic demands of the brain, mechanisms have evolved to couple neuronal
activity to vasodilation, thus increasing local cerebral blood flow and delivery of oxygen and …
activity to vasodilation, thus increasing local cerebral blood flow and delivery of oxygen and …
Brain capillary pericytes exert a substantial but slow influence on blood flow
The majority of the brain's vasculature is composed of intricate capillary networks lined by
capillary pericytes. However, it remains unclear whether capillary pericytes influence blood …
capillary pericytes. However, it remains unclear whether capillary pericytes influence blood …
Pericyte remodeling is deficient in the aged brain and contributes to impaired capillary flow and structure
Deterioration of brain capillary flow and architecture is a hallmark of aging and dementia. It
remains unclear how loss of brain pericytes in these conditions contributes to capillary …
remains unclear how loss of brain pericytes in these conditions contributes to capillary …
Brain microvasculature has a common topology with local differences in geometry that match metabolic load
The microvasculature underlies the supply networks that support neuronal activity within
heterogeneous brain regions. What are common versus heterogeneous aspects of the …
heterogeneous brain regions. What are common versus heterogeneous aspects of the …
Ultrafast two-photon fluorescence imaging of cerebral blood circulation in the mouse brain in vivo
G Meng, J Zhong, Q Zhang, JSJ Wong… - Proceedings of the …, 2022 - National Acad Sciences
Characterizing blood flow dynamics in vivo is critical to understanding the function of the
vascular network under physiological and pathological conditions. Existing methods for …
vascular network under physiological and pathological conditions. Existing methods for …
Network-driven anomalous transport is a fundamental component of brain microvascular dysfunction
F Goirand, T Le Borgne, S Lorthois - Nature communications, 2021 - nature.com
Blood microcirculation supplies neurons with oxygen and nutrients, and contributes to
clearing their neurotoxic waste, through a dense capillary network connected to larger tree …
clearing their neurotoxic waste, through a dense capillary network connected to larger tree …
Oxygen imaging of hypoxic pockets in the mouse cerebral cortex
Consciousness is lost within seconds upon cessation of cerebral blood flow. The brain
cannot store oxygen, and interruption of oxidative phosphorylation is fatal within minutes …
cannot store oxygen, and interruption of oxidative phosphorylation is fatal within minutes …
Phosphorescent NIR emitters for biomedicine: Applications, advances and challenges
PS Chelushkin, JR Shakirova, IS Kritchenkov… - Dalton …, 2022 - pubs.rsc.org
Application of NIR (near-infrared) emitting transition metal complexes in biomedicine is a
rapidly developing area of research. Emission of this class of compounds in the “optical …
rapidly developing area of research. Emission of this class of compounds in the “optical …
Microvascular alterations in Alzheimer's disease
J Steinman, HS Sun, ZP Feng - Frontiers in cellular neuroscience, 2021 - frontiersin.org
Alzheimer's disease (AD) is a neurodegenerative disorder associated with continual decline
in cognition and ability to perform routine functions such as remembering familiar places or …
in cognition and ability to perform routine functions such as remembering familiar places or …