Classic Signaling Pathways in Alveolar Injury and Repair Involved in Sepsis‐Induced ALI/ARDS: New Research Progress and Prospect
W Li, D Li, Y Chen, H Abudou, H Wang, J Cai… - Disease …, 2022 - Wiley Online Library
Sepsis is a common critical clinical disease with high mortality that can cause approximately
10 million deaths worldwide each year. Acute lung injury (ALI) or acute respiratory distress …
10 million deaths worldwide each year. Acute lung injury (ALI) or acute respiratory distress …
Unpuzzling COVID-19: tissue-related signaling pathways associated with SARS-CoV-2 infection and transmission
The highly infective coronavirus disease 19 (COVID-19) is caused by a novel strain of
coronaviruses–the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …
coronaviruses–the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …
[HTML][HTML] STAT3–BDNF–TrkB signalling promotes alveolar epithelial regeneration after lung injury
Alveolar epithelial regeneration is essential for recovery from devastating lung diseases.
This process occurs when type II alveolar pneumocytes (AT2 cells) proliferate and …
This process occurs when type II alveolar pneumocytes (AT2 cells) proliferate and …
Acute lower respiratory tract infection
JP Mizgerd - New England Journal of Medicine, 2008 - Mass Medical Soc
Acute lower respiratory tract infections are a major cause of death and disability, yet the
mechanisms that make such infections so virulent are not entirely understood. This review …
mechanisms that make such infections so virulent are not entirely understood. This review …
[HTML][HTML] The effect of resveratrol on the cardiovascular system from molecular mechanisms to clinical results
Cardiovascular diseases are the leading causes of death worldwide. The cardioprotective
effects of natural polyphenols such as resveratrol (3, 5, 4-trihydroxystilbene) have been …
effects of natural polyphenols such as resveratrol (3, 5, 4-trihydroxystilbene) have been …
Interleukin-6 promotes a sustained loss of endothelial barrier function via Janus kinase-mediated STAT3 phosphorylation and de novo protein synthesis
H Alsaffar, N Martino, JP Garrett… - American Journal of …, 2018 - journals.physiology.org
Vascular leakage is a hallmark of the inflammatory response. Acute changes in endothelial
permeability are due to posttranslational changes in intercellular adhesion and cytoskeleton …
permeability are due to posttranslational changes in intercellular adhesion and cytoskeleton …
Transcriptional control of lung morphogenesis
Y Maeda, V Dave, JA Whitsett - Physiological reviews, 2007 - journals.physiology.org
The vertebrate lung consists of multiple cell types that are derived primarily from endodermal
and mesodermal compartments of the early embryo. The process of pulmonary …
and mesodermal compartments of the early embryo. The process of pulmonary …
Stat3 regulates genes common to both wound healing and cancer
DJ Dauer, B Ferraro, L Song, B Yu, L Mora, R Buettner… - Oncogene, 2005 - nature.com
Wound healing and cancer are both characterized by cell proliferation, remodeling of
extracellular matrix, cell invasion and migration, new blood vessel formation, and …
extracellular matrix, cell invasion and migration, new blood vessel formation, and …
Novel signal transducer and activator of transcription 3 (STAT3) mutations, reduced TH17 cell numbers, and variably defective STAT3 phosphorylation in hyper-IgE …
ED Renner, S Rylaarsdam, S Aňover-Sombke… - Journal of Allergy and …, 2008 - Elsevier
BACKGROUND: Hyper-IgE syndrome (HIES) is a rare, autosomal-dominant
immunodeficiency characterized by eczema, Staphylococcus aureus skin abscesses …
immunodeficiency characterized by eczema, Staphylococcus aureus skin abscesses …
STAT3 tyrosine phosphorylation is critical for interleukin 1 beta and interleukin-6 production in response to lipopolysaccharide and live bacteria
Both interleukin 1 beta (IL-1β) and interleukin-6 (IL-6) are pro-inflammatory cytokines that
play a major role in inflammatory diseases as well as cancer. In this work we investigated …
play a major role in inflammatory diseases as well as cancer. In this work we investigated …