Classic Signaling Pathways in Alveolar Injury and Repair Involved in Sepsis‐Induced ALI/ARDS: New Research Progress and Prospect

W Li, D Li, Y Chen, H Abudou, H Wang, J Cai… - Disease …, 2022 - Wiley Online Library
Sepsis is a common critical clinical disease with high mortality that can cause approximately
10 million deaths worldwide each year. Acute lung injury (ALI) or acute respiratory distress …

Unpuzzling COVID-19: tissue-related signaling pathways associated with SARS-CoV-2 infection and transmission

DS Battagello, G Dragunas, MO Klein… - Clinical …, 2020 - portlandpress.com
The highly infective coronavirus disease 19 (COVID-19) is caused by a novel strain of
coronaviruses–the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …

[HTML][HTML] STAT3–BDNF–TrkB signalling promotes alveolar epithelial regeneration after lung injury

AJ Paris, KE Hayer, JH Oved, DC Avgousti… - Nature Cell …, 2020 - nature.com
Alveolar epithelial regeneration is essential for recovery from devastating lung diseases.
This process occurs when type II alveolar pneumocytes (AT2 cells) proliferate and …

Acute lower respiratory tract infection

JP Mizgerd - New England Journal of Medicine, 2008 - Mass Medical Soc
Acute lower respiratory tract infections are a major cause of death and disability, yet the
mechanisms that make such infections so virulent are not entirely understood. This review …

[HTML][HTML] The effect of resveratrol on the cardiovascular system from molecular mechanisms to clinical results

R Gal, L Deres, K Toth, R Halmosi, T Habon - International journal of …, 2021 - mdpi.com
Cardiovascular diseases are the leading causes of death worldwide. The cardioprotective
effects of natural polyphenols such as resveratrol (3, 5, 4-trihydroxystilbene) have been …

Interleukin-6 promotes a sustained loss of endothelial barrier function via Janus kinase-mediated STAT3 phosphorylation and de novo protein synthesis

H Alsaffar, N Martino, JP Garrett… - American Journal of …, 2018 - journals.physiology.org
Vascular leakage is a hallmark of the inflammatory response. Acute changes in endothelial
permeability are due to posttranslational changes in intercellular adhesion and cytoskeleton …

Transcriptional control of lung morphogenesis

Y Maeda, V Dave, JA Whitsett - Physiological reviews, 2007 - journals.physiology.org
The vertebrate lung consists of multiple cell types that are derived primarily from endodermal
and mesodermal compartments of the early embryo. The process of pulmonary …

Stat3 regulates genes common to both wound healing and cancer

DJ Dauer, B Ferraro, L Song, B Yu, L Mora, R Buettner… - Oncogene, 2005 - nature.com
Wound healing and cancer are both characterized by cell proliferation, remodeling of
extracellular matrix, cell invasion and migration, new blood vessel formation, and …

Novel signal transducer and activator of transcription 3 (STAT3) mutations, reduced TH17 cell numbers, and variably defective STAT3 phosphorylation in hyper-IgE …

ED Renner, S Rylaarsdam, S Aňover-Sombke… - Journal of Allergy and …, 2008 - Elsevier
BACKGROUND: Hyper-IgE syndrome (HIES) is a rare, autosomal-dominant
immunodeficiency characterized by eczema, Staphylococcus aureus skin abscesses …

STAT3 tyrosine phosphorylation is critical for interleukin 1 beta and interleukin-6 production in response to lipopolysaccharide and live bacteria

L Samavati, R Rastogi, W Du, M Hüttemann, A Fite… - Molecular …, 2009 - Elsevier
Both interleukin 1 beta (IL-1β) and interleukin-6 (IL-6) are pro-inflammatory cytokines that
play a major role in inflammatory diseases as well as cancer. In this work we investigated …