We demonstrate the formation of diverse peptide nanostructures, which are “out of
equilibrium” based on a single dipeptide gelator. These structures represent the differential …

Diphenylalanine (FF) peptides exhibit a unique ability to self-assemble into nanotubes with
confined water molecules playing pivotal roles in their structure and function. This study …

Prions are infective proteins, which can self-assemble into different strain conformations,
leading to different disease phenotypes. An increasing number of studies suggest that prion …

Abstract Alzheimer's disease (AD), the most prevalent neurodegenerative disease, is
characterized by extracellular accumulation of amyloid-beta protein (Aβ), which is believed …

Amyloid proteins are linked to the pathogenesis of several diseases including Alzheimer's
disease, but at the same time a range of functional amyloids are physiologically important in …

The self-assembly of aromatic amino acids has been widely studied due to their ability to
form well-defined amyloid-like fibrillar structures. Herein, for the first time, we report the …

Mutations in RPE65 or lecithin-retinol acyltransferase (LRAT) disrupt 11-cis-retinal recycling
and cause Leber congenital amaurosis (LCA), the most severe retinal dystrophy in early …

Type-2 diabetes mellitus (DM-2) is a conformational disease involving intrinsically
disordered islet amyloid polypeptide (IAPP), in which a structural transition from …

Diphenylalanine peptide (FF), which self-assembles into rigid tubular nanostructures, is a
very short core recognition motif in Alzheimer's disease β-amyloid (Aβ) polypeptide …

Alzheimer's disease (AD) is the most common cause of dementia. The cardinal
neuropathological characteristic of AD is the accumulation of amyloid-β (Aβ) into …