Numerous supramolecular protein assemblies had been demonstrated to have either
physiological or pathological activities. The most significant case of disease-associated self …

Background The misfolding and deposition of amyloid beta (Aβ) in human brain is the main
hallmark of Alzheimer's disease (AD) pathology. One of the drivers of Alzheimer´ s …

Peptides are ideal biologicals for targeted drug delivery and have also been increasingly
employed as theranostic tools in treating various diseases, including cancer, with minimal or …

This Perspective outlines our current understanding of molecular gels composed of short
and ultrashort peptides over the past 20 years. We discuss in detail the state of the art …

The aggregation of amyloid polypeptide plays a crucial role in inducing various chronic
diseases, such as neurodegenerative diseases and type II diabetes. Up to date, amyloid …

Background The eye lens is composed of fiber cells that are filled with α-, β-and γ-crystallins.
The primary function of crystallins is to maintain the clarity of the lens through ordered …

The title zwitterion (2S)-2-azaniumyl-1-hydroxy-3-phenylpropan-1-olate, C9H11NO2, also
known as l-phenylalanine, was characterized using synchrotron X-rays. It crystallized in the …

Protein aggregation, involving the formation of dimers, oligomers, and fibrils, is associated
with many human diseases. Type 2 diabetes is one of the common amyloidosis and linked …

Oligomeric intermediates are possible cytotoxic species in diseases associated with amyloid
deposits. Understanding the early steps of fibril formation at atomic details may provide …

Ion-mobility mass spectrometry is utilized to examine the metacluster formation of serine,
asparagine, isoleucine, and tryptophan. These amino acids are representative of different …