The role of water in promoting the formation of protofilaments (the basic building blocks of
amyloid fibrils) is investigated using fully atomic molecular dynamics simulations. Our model …

Background The polypeptides involved in amyloidogenesis may be globular proteins with a
defined 3D-structure or natively unfolded proteins. The first class includes polypeptides such …

Molecular self-assembly offers new routes for the fabrication of novel materials at the nano-
scale. Peptide-based nanostructures represent nano-objects of particular interest, as they …

Amyloid fibrils in which specific proteins have polymerized into a cross-β-sheet structure are
found in about 20 diseases. In contrast to the close structural similarity of fibrils formed in …

Aggregation of a biotherapeutic is of significant concern and judicious process and
formulation development is required to minimize aggregate levels in the final product …

Molecular self-assembly offers unique directions for the fabrication of novel supramolecular
structures and advanced materials. The inspiration for the development of such structures is …

Islet amyloid polypeptide (aka IAPP, amylin) is a 37 amino acid hormone that has long been
associated with the progression of type II diabetes mellitus (TIIDM) disease. The endocrine …

One hundred years ago, Alois Alzheimer observed a relationship between cognitive
impairment and the presence of plaque in the brains of patients suffering from the disease …

Islet amyloid polypeptide (IAPP, amylin) is responsible for amyloid formation in type 2
diabetes and in transplanted islets. The flavanol (−)-epigallocatechin-3-gallate [EGCG;(2 R …

The rational design of amyloid oligomer inhibitors is yet an unmet drug development need.
Previous studies have identified the role of tryptophan in amyloid recognition, association …