Mammalian eggs (oocytes) are formed during fetal life and establish associations with
somatic cells to form primordial follicles that create a store of germ cells (the primordial pool) …

BACKGROUND In a growth phase occurring during most of folliculogenesis, the oocyte
produces and accumulates molecules and organelles that are fundamental for the …

STUDY QUESTION Can complete oocyte development be achieved from human ovarian
tissue containing primordial/unilaminar follicles and grown in vitro in a multi-step culture to …

Cryopreservation of ovarian tissue to preserve the fertility of girls and young women at high
risk of sterility is now widely practiced. Pieces of cryopreserved ovarian cortex can be …

Apoptosis causes elimination of more than 99% of germ cells from cohort of ovary through
follicular atresia. Less than 1% of germ cells, which are culminated in oocytes further …

The development of germ cells relies on contact and communication with neighboring
somatic cells that provide metabolic support and regulatory signals. In females, contact is …

Mammalian reproduction hinges upon the timely ovulation of a fully differentiated oocyte.
This event is the culmination of a complex and dynamic developmental relationship between …

BACKGROUND Fertility loss during female ageing is associated with increasing basal FSH
and decreasing anti-Müllerian hormone (AMH) concentrations, together with compromised …

Removal and storage of ovarian cortical tissue is currently offered to young female cancer
patients undergoing potentially sterilizing chemotherapy and/or radiotherapy. For patients at …

STUDY QUESTION What is the expression pattern of microRNAs (miRNAs) in human
cumulus–oocyte complexes (COCs)? SUMMARY ANSWER Several miRNAs are enriched …