BACKGROUND Human female meiosis is particularly error prone, leading to the generation
of aneuploidy, a problem which increases dramatically with advancing age. Despite being of …

Meiotic maturation and cumulus expansion are essential for the generation of a
developmentally competent gamete, and both processes can be recapitulated in vitro. We …

Oocytes from medium-sized antral follicles have already completed their growth phase and,
if released from the follicular environment and cultured in vitro, are able to resume the …

Common aspects of infertility can be seen across several species. In humans, dairy cows,
and mares there is only a 25-35% chance of producing a live offspring after a single …

Introduction Morphokinetic analysis using a closed time-lapse monitoring system
(EmbryoScope+™) provides quantitative metrics of meiotic progression and cumulus …

Female meiosis is unique in that an asymmetrically positioned meiotic spindle expels
chromosomes into tiny, non-developing polar bodies. The extrusion of chromosomes into …

Ovarian cryopreservation rapidly developed from basic science to clinical application and
can now be used to preserve the fertility of girls and young women at high risk of sterility …

BACKGROUND The use of ovarian stimulation, to stimulate a multi-follicular response for
assisted reproduction treatments, may force the production of oocytes from follicles that do …

This study aimed to evaluate the effects of donor age on lipid metabolism during in vitro
maturation (IVM) of pigs cumulus‐oocyte complexes (COCs). We evaluated transcript levels …

The maximum number of germ cells is present during the fetal life in mammals. Follicular
atresia results in rapid depletion of germ cells from the cohort of the ovary. At the time of …