The tumor microenvironment represents a complex network, in which tumor cells not only
communicate with each other but also with stromal and immune cells. Current research has …

Two broad categories of extracellular vesicles (EVs), exosomes and shed microvesicles
(sMVs), which differ in size distribution as well as protein and RNA profiles, have been …

Sorafenib is the first-line chemotherapeutic therapy for advanced hepatocellular carcinoma
(HCC). However, sorafenib resistance significantly limits its therapeutic efficacy, and the …

Tumor-educated blood platelets (TEPs) are implicated as central players in the systemic and
local responses to tumor growth, thereby altering their RNA profile. We determined the …

Intercellular communication via cell-released vesicles is a very important process for both
normal and tumor cells. Cell communication may involve exosomes, small vesicles of …

Tumor cells actively produce, release, and utilize exosomes to promote tumor growth.
Mechanisms through which tumor-derived exosomes subserve the tumor are under intense …

Exosomes play a role in cell-to-cell signaling and serve as possible biomarkers. Isolating
exosomes with reliable quality and substantial concentration is a major challenge. Our …

Exosomes are 40–150 nm extracellular vesicles that are released from a multitude of cell
types, and perform diverse cellular functions including intercellular communication, antigen …

Within the past decade, extracellular vesicles have emerged as important mediators of
intercellular communication, being involved in the transmission of biological signals …

Background Extracellular communication within the tumor microenvironment plays a critical
role in tumor progression. Although exosomes can package into long non-coding RNAs …