Enzymatic reactions and noncovalent (ie, supramolecular) interactions are two fundamental
nongenetic attributes of life. Enzymatic noncovalent synthesis (ENS) refers to a process …

Innovative methods for engineering cancer cell membranes promise to manipulate cell–cell
interactions and boost cell-based cancer therapeutics. Here, we illustrate an in situ …

The cooperation relation between biomolecules and nanomaterials makes up a beautiful
tale about nanoscale chiral sensing and separation. Biomolecules are considered a …

Abstract Calcium (Ca 2+) overload therapy is an efficient cancer treatment modality that
increases aberrant cytoplasmic Ca 2+ accumulation and activates mitochondrial apoptotic …

Immunogenic cell death (ICD) approaches by encumbering mitochondrial functions provide
great promise for the treatment of malignant tumors, but these kinds of ICD strategies are still …

Protein preorganization is ubiquitous in nature and enables subtle structural
rearrangements and precise function executions, making it an attractive approach for …

Proteins and peptides can assemble into functional amyloid fibrils with distinct architectures.
These amyloid fibrils can fulfil various biological functions in living organisms, and then be …

Background and purpose: Activation of liver X receptor (LXR) by its ligand T0901317 (T317)
enhances interferon-γ (IFNγ) production to inhibit tumor growth. However, induction of …

Chemotherapy benefits can be greatly boosted by developing multifunctional prodrug
nanoplatforms with high drug loading and spatially and temporally regulated drug release …

The creation of artificial enzymes to mimic natural enzymes remains a great challenge owing
to the complexity of the structural arrangement of the essential amino acids in catalytic …