Malignant bowel obstruction (MBO) is a frequent complication in advanced cancer patients,
especially in those with abdominal tumors. Clinical management of MBO requires a specific …

Despite the increasing clinical use of transdermal buprenorphine, questions have persisted
about the possibility of a ceiling effect for analgesia, its combination with other μ‐opioid …

Opioids and sedative drugs are commonly used to control symptoms in patients with
advanced cancer. However, it is often assumed that the use of these drugs inevitably results …

Background This is the third updated version of a Cochrane review first published in Issue 4,
2003 of The Cochrane Library and first updated in 2007. Morphine has been used for many …

Pain is a common symptom associated with cancer and its treatment. Pain management is
an important aspect of oncologic care, and unrelieved pain significantly comprises overall …

As a result of the undesired action of opioids on the gastrointestinal (GI) tract, patients
receiving opioid medication for chronic pain often experience opioid‐induced bowel …

Clinical studies comparing the response and side effects of various opioids have not been
able to show robust differences between drugs. Hence, recommendations of the regulatory …

Malignant bowel obstruction (MBO) is a common and distressing outcome particularly in
patients with bowel or gynaecological cancer. Radiological imaging, particularly with CT, is …

Background: Opioid use in patients with renal impairment can lead to increased adverse
effects. Opioids differ in their effect in renal impairment in both efficacy and tolerability. This …

Background Many people with cancer experience moderate to severe pain that requires
treatment with strong opioids, such as oxycodone and morphine. Strong opioids are …