Opioid-induced bowel dysfunction (OIBD) comprises gastrointestinal (GI) symptoms,
including dry mouth, nausea, vomiting, gastric stasis, bloating, abdominal pain, and opioid …

Background: Oxycodone is often used as an opioid analgesic for moderate to severe cancer-
related pain, but its use varies across Europe. This systematic literature review forms the …

Breakthrough pain (BTP) is a transient exacerbation of pain that occurs either
spontaneously, or in relation to a specific predictable or unpredictable trigger, despite …

Cancer-induced bone pain (CIBP) is a major clinical problem with up to 85% of patients with
bony metastases having pain, often associated with anxiety and depression, reduced …

Background Thirty percent to ninety percent of cancer patients suffer from pain, including
neuropathic pain (NP), which results in great burden for cancer patients. Thus, it was of great …

Background This study estimates prevalence, management, and relief of pain during the last
3 months of life of a representative sample of dying cancer patients in Italy. Patients and …

The antinociceptive effect of morphine and oxycodone is mediated preferentially at μ and κ
receptors, respectively. The aim of this study was to evaluate the analgesic profile of the …

The management of chronic pain remains a challenge because of its complexity and
unpredictable response to pharmacological treatment. In addition, accurate pain …

Background: Despite thousands of papers, the value of quality of life (QoL) in curing disease
remains uncertain. Until now, we lacked tools for the diagnosis and specific treatment of …

Metastatic bone cancer causes severe pain that is primarily treated with opioids. A model of
bone cancer pain in which the progression of cancer pain and bone destruction is tightly …