Background: Methadone is an opioid analgesic of step 3 of the World Health Organization
(WHO) analgesic ladder. Aim and Methods: To outline pharmacodynamics …

A titration procedure using immediate-release morphine given 4-hourly is recommended
during start of oral morphine for cancer pain. This recommendation is not based on evidence …

The aim of this systematic review was to evaluate the evidence that oral morphine can be
recommended as the first choice opioid in the treatment of moderate to severe cancer pain …

BACKGROUND: Pain after thoracotomy is common. The objective of this study was to
assess whether pain 3 months postthoracotomy negatively impacts quality of life …

To evaluate the efficacy and tolerability of oxycodone in cancer-related pain, we conducted
a systematic review of randomized controlled trials. Four studies, comparing oral oxycodone …

The use of supplemental doses of opioids is commonly suggested to manage breakthrough
pain. A comparative study of intravenous morphine (IV-MO) and oral transmucosal fentanyl …

Rationale Nonmedical use and abuse of prescription opioids is a significant problem in the
USA. Little attention has been paid to assessing the relative psychopharmacological profile …

Controversies exist about the definition and epidemiology of breakthrough cancer pain
(BTcP), the pharmacological treatment options, drug dosing, and how to select the …

Breakthrough pain is a common and distinct component of cancer pain that is usually
managed with normal release opioids (also known as rescue medication) either before or …

Background: The role of preoperative gabapentin in postoperative pain management is not
clear, particularly in patients receiving regional blockade. Patients undergoing thoracotomy …